DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Got1 and got2b

DIOPT Version :9

Sequence 1:	NP_725534.1	Gene:	Got1 / 36782	FlyBaseID:	FBgn0001124	Length:	437	Species:	Drosophila melanogaster
Sequence 2:	NP_956283.1	Gene:	got2b / 335974	ZFINID:	ZDB-GENE-030131-7917	Length:	428	Species:	Danio rerio

Alignment Length:	409	Identity:	201/409 - (49%)
Similarity:	259/409 - (63%)	Gaps:	7/409 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LQNFQLSTMSIYADVPKGPAIEVFALTQAFKDDSNPNKVNLSVGAYRTDAGVPWVLPVVRKTEIS 78
            |.:..:...|.:.:|..||...:..:|:|||.|:|..|:||.|||||.|.|.|:||..|||.|..
Zfish    20 LASLPIRASSWWTEVQMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLNCVRKAESL 84

  Fly    79 IASDEQVNHEYLPVTGLETFTNAATELVLGADSPAIKENRAFGVQTISGTGALRVAADFL---HT 140
            ||| :.::.|||.:.||..|..|..||.||.||..:|..|:..||||||||:|||.|:||   ||
Zfish    85 IAS-KALDKEYLGIVGLGDFNKACAELALGQDSDVLKSKRSITVQTISGTGSLRVGANFLSRFHT 148

  Fly   141 QLNRNVVYYSNPTWENHHKIFCDAGFTTVKSYRYWDQNKRELDFKNMLADLNDAPPGAVIILHAC 205
             :.|: ||...|:|.||..||.|||. .:|:|||:|......||...|.|::..|..:||:||||
Zfish   149 -VARD-VYLPKPSWGNHTPIFRDAGM-QLKAYRYYDPATCGFDFTGALDDISKIPQNSVILLHAC 210

  Fly   206 AHNPTGIDPTQEQWTELADLMEKKKLFPLFDSAYQGFASGDPDRDAWAARYFVQRGFELFICQSF 270
            ||||||:||..|||.||:.:::::||.|.||.|||||||||.||||||.|||:::|..:.:.|||
Zfish   211 AHNPTGVDPRPEQWKELSAVIKERKLLPFFDMAYQGFASGDIDRDAWAVRYFIEQGHNILLSQSF 275

  Fly   271 AKNFGLYCERTGNLAVVQKNGATKAAVHSQLTLLIRGQYSNPPAYGARIVSKVLNTPELRKEWMA 335
            |||.|||.||.|...||..:......|.|||.:|||..|||||..||||.|.:|.|||||..|:.
Zfish   276 AKNMGLYGERVGGFTVVCGDAEEAKRVESQLKILIRPIYSNPPMNGARIASTILTTPELRSTWLE 340

  Fly   336 SIQAMSSRIREMRTALRDKLVALGTPGTWDHIVNQIGMFSYTGLNESHVRVLIDQYHIYLLKTGR 400
            .::.|:.||..||..|...|...|:...|.|:.:|||||.:|||....|..|...:.:|:.|.||
Zfish   341 EVKGMADRIIRMREMLVTNLKKEGSTHNWQHVTDQIGMFCFTGLKPEQVERLTKDFSVYMTKDGR 405

  Fly   401 ISMSGLNKGNVEYVAKAIH 419
            ||::|:..|||||:|.|||
Zfish   406 ISVAGVTSGNVEYLAHAIH 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Got1	NP_725534.1	PTZ00376	21..423	CDD:240390	200/402 (50%)
Got1	NP_725534.1	Aminotran_1_2	49..418	CDD:278580	187/371 (50%)
got2b	NP_956283.1	PLN02397	26..428	CDD:215222	200/403 (50%)
got2b	NP_956283.1	Aminotran_1_2	55..423	CDD:278580	187/371 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1448
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62835
OrthoDB	1	1.010	-	-		D1104596at2759
OrthoFinder	1	1.000	-	-		FOG0000707
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100337
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2019
SonicParanoid	1	1.000	-	-		X428
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.760