DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Got1 and got-2.2

DIOPT Version :9

Sequence 1:	NP_725534.1	Gene:	Got1 / 36782	FlyBaseID:	FBgn0001124	Length:	437	Species:	Drosophila melanogaster
Sequence 2:	NP_741810.1	Gene:	got-2.2 / 180897	WormBaseID:	WBGene00015778	Length:	414	Species:	Caenorhabditis elegans

Alignment Length:	397	Identity:	190/397 - (47%)
Similarity:	260/397 - (65%)	Gaps:	2/397 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SIYADVPKGPAIEVFALTQAFKDDSNPNKVNLSVGAYRTDAGVPWVLPVVRKTEISIASDEQVNH 87
            |.::.|..||...:..:|:|||.||||.|:||.|||||.|.|.|:|||.|::.|..:.: ..::.
Worm    16 SWWSHVEMGPPDAILGVTEAFKADSNPKKINLGVGAYRDDQGKPFVLPSVKEAERQVIA-ANLDK 79

  Fly    88 EYLPVTGLETFTNAATELVLGADSPAIKENRAFGVQTISGTGALRVAADFLHTQLNRNVVYYSNP 152
            ||..:.||..||..:.:|.||.:|..||..|.|..|:||||||||:.::||.......|:|...|
Worm    80 EYAGIVGLPEFTKLSAQLALGENSDVIKNKRIFTTQSISGTGALRIGSEFLSKYAKTKVIYQPTP 144

  Fly   153 TWENHHKIFCDAGFTTVKSYRYWDQNKRELDFKNMLADLNDAPPGAVIILHACAHNPTGIDPTQE 217
            ||.||..||..|| ..||.|||:|::....|....|||:...|.|:.|:||||||||||:||:::
Worm   145 TWGNHVPIFKFAG-VDVKQYRYYDKSTCGFDETGALADIAQIPEGSTILLHACAHNPTGVDPSRD 208

  Fly   218 QWTELADLMEKKKLFPLFDSAYQGFASGDPDRDAWAARYFVQRGFELFICQSFAKNFGLYCERTG 282
            ||.:::|:::|:.||..||.|||||||||.|.||:|.||||::|..:.:.||||||.|||.||.|
Worm   209 QWKKISDIVKKRNLFVFFDMAYQGFASGDVDNDAFAVRYFVEQGHNIVLSQSFAKNMGLYGERVG 273

  Fly   283 NLAVVQKNGATKAAVHSQLTLLIRGQYSNPPAYGARIVSKVLNTPELRKEWMASIQAMSSRIREM 347
            ..:||..:....|.|.||:.:|||..|||||.:||||.|::|..|.|.|:|:..::.|:.||..|
Worm   274 AFSVVTSDADEAARVASQVKILIRPLYSNPPVHGARIASRILADPALNKQWLGDVKLMADRIITM 338

  Fly   348 RTALRDKLVALGTPGTWDHIVNQIGMFSYTGLNESHVRVLIDQYHIYLLKTGRISMSGLNKGNVE 412
            ||.|:|.|...|:...|:||.||||||.:||:|...|..||.::.:||.|.||||::|::..||.
Worm   339 RTTLKDLLAKEGSTRNWEHITNQIGMFCFTGINPQQVEKLIKEHSVYLTKDGRISVAGISSNNVA 403

  Fly   413 YVAKAIH 419
            |:|.|:|
Worm   404 YLAHALH 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Got1	NP_725534.1	PTZ00376	21..423	CDD:240390	190/397 (48%)
Got1	NP_725534.1	Aminotran_1_2	49..418	CDD:278580	177/368 (48%)
got-2.2	NP_741810.1	AAT_I	1..414	CDD:302748	190/397 (48%)
got-2.2	NP_741810.1	Aminotran_1_2	42..409	CDD:278580	177/368 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62835
OrthoDB	1	1.010	-	-		D1104596at2759
OrthoFinder	1	1.000	-	-		FOG0000707
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100337
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2019
SonicParanoid	1	1.000	-	-		X428
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860