Protein Alignment Jhe and CES2

DIOPT Version :9

• Sequence 1: NP_001163166.1
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_001352334.1
• Gene: CES2 / 8824
• HGNCID: 1864
• Length: 559
• Species: Homo sapiens
• Alignment Length: 598
• Identity: 176/598 - (29%)
• Similarity: 260/598 - (43%)
• Gaps: 96/598 - (16%)

  Fly     9 LLLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKGTNLQGYQSERFEAFMGIPYALPPIGDLRF 73
            ||||  |:.|.|...|:............|:..:||.| .|.|:     |:|||:|.||:|.|||
Human    17 LLLL--LVRGQGQDSASPIRTTHTGQVLGSLVHVKGAN-AGVQT-----FLGIPFAKPPLGPLRF 73

  Fly    74 SNPKVMPKLLGMYDASAPKMDCIQK------------NYLLPTPVVYGDEDCLYLNVYRP--EIR 124
            :.|:......|:.|.:.....|:|.            |...|:..:  .||||||::|.|  ...
Human    74 APPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSM--SEDCLYLSIYTPAHSHE 136

  Fly   125 KSALPVMVYIHGGGFFGGSA----GPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGN 185
            .|.|||||:||||....|.|    |..:...|      .|::|.:.||||..||.||.|...:||
Human   137 GSNLPVMVWIHGGALVFGMASLYDGSMLAALE------NVVVVIIQYRLGVLGFFSTGDKHATGN 195

  Fly   186 FGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVP 250
            :|..||..||||||:||..|||:|.||||||:||||.:....::||.|.||||..|..||.|.:|
Human   196 WGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLP 260

  Fly   251 FAIAEQPLEQARLLAEFADVPDARNLSTVKLT-KALRRINATKLLNAGDGLKYWDVDHMTN-FR- 312
                       .|:|..|||     :|||... .|..::::..|:....|....::..:.. |:
Human   261 -----------GLIASSADV-----ISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKM 309

  Fly   313 -PVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNIL-----GNETLRQSFNL 371
             |.|.:|:    ||..||.::||......:|.::|....|....:..::     ..|..|::...
Human   310 IPGVVDGV----FLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQA 370

  Fly   372 RFDELLQELLEFPASFSQDRREKMMDLLVEVYFQGQHEVNELTVQGFMNLISDRGFKQPLYNTIH 436
            ...::| .||..|.:|.        |||.|.|.....:...|..| |..:::|..|..|.....|
Human   371 ALQKML-TLLMLPPTFG--------DLLREEYIGDNGDPQTLQAQ-FQEMMADSMFVIPALQVAH 425

  Fly   437 KNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPLLFPDFQRNSTEAK 501
            ......  |||.|.|.:|.  |:.......::...:|    |:|.::|||.......:....|.:
Human   426 FQCSRA--PVYFYEFQHQP--SWLKNIRPPHMKADHG----DELPFVFRSFFGGNYIKFTEEEEQ 482

  Fly   502 VIHSFVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICDYHEFANAPDAYQGFEVHVASEFQT 566
            :....:.|:.:||:.|.| |.|.|....:...:.:      |.:....|...:..:.|
Human   483 LSRKMMKYWANFARNGNP-NGEGLPHWPLFDQEEQ------YLQLNLQPAVGRALKAH------- 533

  Fly   567 DRVNLWSHILNEK 579
             |:..|...|.:|
Human   534 -RLQFWKKALPQK 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	160/513 (31%)
CES2	NP_001352334.1	COesterase	30..538	CDD:306613	166/574 (29%)
		Prevents secretion from ER. /evidence=ECO:0000255	556..559

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142679
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840