DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhe and TG

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_003226.4	Gene:	TG / 7038	HGNCID:	11764	Length:	2768	Species:	Homo sapiens

Alignment Length:	518	Identity:	147/518 - (28%)
Similarity:	226/518 - (43%)	Gaps:	83/518 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 PSV-----GCLKGTN--LQ-GYQSERFEAFMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKM 93
            |||     |.|.|.:  :| |...::.:.|:|:|||.||:.:.||..|:.: ...|.:|||.|:.
Human  2199 PSVPISTHGRLLGRSQAIQVGTSWKQVDQFLGVPYAAPPLAERRFQAPEPL-NWTGSWDASKPRA 2262

  Fly    94 DCIQKNYLLPT-PVVYGDEDCLYLNVYRPEIRKSALPVMVYIHGGGFFGGSAG-PGVTGPEYFMD 156
            .|.|......| |.|  .||||||||:.|:.......|:|:.|.......|.| |.:.| .:...
Human  2263 SCWQPGTRTSTSPGV--SEDCLYLNVFIPQNVAPNASVLVFFHNTMDREESEGWPAIDG-SFLAA 2324

  Fly   157 SGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGG 221
            .|.:|:||.:||:|.|||||:....:|||:||.||..||.|||.:||.|||||:||::.....|.
Human  2325 VGNLIVVTASYRVGVFGFLSSGSGEVSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGA 2389

  Fly   222 VAAHMHLLSPRSHG--LFHRVISMSGTANVPFAIA--EQPLEQARLLAEFADVPDARNLSTVKLT 282
            ..|.:|||:.|:..  ||.|.:.|.|:|..|.|:.  |:..:||..||:....|.:   |:.::.
Human  2390 DVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPMS---SSQEVV 2451

  Fly   283 KALRRINA-------TKLLNAGDGLKYWDVDHMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPTS 340
            ..||:..|       ||||.......||.        ||::     ..||...|...|.:.:...
Human  2452 SCLRQKPANVLNDAQTKLLAVSGPFHYWG--------PVID-----GHFLREPPARALKRSLWVE 2503

  Fly   341 IPLLLGTVPGEGAV---RVVNILGNETLRQSFNLRFDELLQELLEFPASFSQDRREKMMDLLVEV 402
            :.||:|:...:|.:   :.|........|.|....|.:.||.      |...:..:..::.....
Human  2504 VDLLIGSSQDDGLINRAKAVKQFEESRGRTSSKTAFYQALQN------SLGGEDSDARVEAAATW 2562

  Fly   403 YFQGQHEVNELTVQGFMNLISDRGFKQPLYNTIHKN--VCHTPNPVYLYS-------FNYQGPLS 458
            |:..:|..::..           .|.:.|.|.....  :|...:....::       |.|..|.:
Human  2563 YYSLEHSTDDYA-----------SFSRALENATRDYFIICPIIDMASAWAKRARGNVFMYHAPEN 2616

  Fly   459 YASAYTSANVTGKYGVVHCDDLLYLFRSPLLFPDFQ-RNSTEAKVIH-SFVDYFVHFAKFGKP 519
            |          |...:....|:.:....| .:|.:: :.|.|.|.:. ..:.||.||.:.|.|
Human  2617 Y----------GHGSLELLADVQFALGLP-FYPAYEGQFSLEEKSLSLKIMQYFSHFIRSGNP 2668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	144/510 (28%)
TG	NP_003226.4	TY	33..92	CDD:238114
		TY	95..160	CDD:238114
		TY	300..358	CDD:238114
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..545
		Thyroglobulin_1	599..658	CDD:395039
		Thyroglobulin_1	662..724	CDD:395039
		TY	729..>776	CDD:412186
		TY	<892..922	CDD:412186
		TY	1004..1073	CDD:238114
		TY	1077..1145	CDD:238114
		TY	1149..1210	CDD:238114
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1456..1469
		Ephrin_rec_like	1465..1510	CDD:400166
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1470..1486
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1487..1503
		TY	1520..1567	CDD:214561
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	1603..1723
		Type IIIB. /evidence=ECO:0000269\|PubMed:8797845	1724..1892
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	1893..1995
		Type IIIB. /evidence=ECO:0000269\|PubMed:8797845	1996..2129
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	2130..2187
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768		147/518 (28%)
		COesterase	2197..2718	CDD:395084	147/518 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2727..2768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142738
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7868
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.790