DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhe and Ces1a

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001177304.1	Gene:	Ces1a / 679817	RGDID:	1583671	Length:	563	Species:	Rattus norvegicus

Alignment Length:	595	Identity:	162/595 - (27%)
Similarity:	259/595 - (43%)	Gaps:	116/595 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PPSVGCLKG------TNLQGYQSERFEAFMGIPYALPPIGDLRFSNPK------------VMPKL 82
            ||.|..|:|      .:|:|: ::....|:|:|:|.||:|.|||:.|:            ..|.:
  Rat    23 PPVVDTLQGKVLGKYISLEGF-TQPVAVFLGVPFAKPPLGSLRFAPPQPAESWSFVKNATSYPPM 86

  Fly    83 LGMYDASAPKMDCIQKNYLLPTPVVYGDEDCLYLNVYRPE--IRKSALPVMVYIHGGGFFGGSA- 144
            ........|.:..:..|.|...|:.| .|||||||:|.|.  ..|..|||||::||||...|.|
  Rat    87 CSQITGVGPVLSEVFTNQLENVPLEY-SEDCLYLNIYSPTDLTSKDRLPVMVWVHGGGLLSGGAS 150

  Fly   145 ---GPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFG 206
               |..::..|      :|::|.:.||||.:|||||.|....||:|..||..||:|||.||..||
  Rat   151 TFDGLALSTHE------KVVVVVIQYRLGIWGFLSTGDEHSRGNWGHFDQVAALQWVQNNIVNFG 209

  Fly   207 GDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLAE-FADV 270
            |||..||:||:||||.:..:.:|||.:..||||.||.||.|..|....    |..||.|| .|..
  Rat   210 GDPNSVTLFGESAGGESVSVLVLSPLTKNLFHRAISESGVALTPCLFR----ENTRLAAEQVAIA 270

  Fly   271 PDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVD------HMTNFRPVVEEGLEVDAFLNAHP 329
            ......::..:.:.||.....:||.....:|::.:|      ....|...|.:|:    .|...|
  Rat   271 TGCAATTSADIVRCLREKTEEELLATTLKMKFFALDLHGDPRESYPFLTTVIDGV----LLPKAP 331

  Fly   330 MDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNETLRQSFNLRFDELLQELLEFPASFSQDRREK 394
            .::|::....::|.::|          :|       :|.|..    .:..::.:|.|.|:..::.
  Rat   332 EEILSEKNFNTVPYIVG----------IN-------KQEFGW----FIPTMMGYPLSESKLDQKT 375

  Fly   395 MMDLLVEVY----------------FQGQHEVNELTVQGFMNLISDRGFKQP--LYNTIHKNVCH 441
            ...||.:.|                :.|..:..:.....|::::.|..|..|  :....|::...
  Rat   376 ATSLLWKSYPLTNISKELTPVATEKYLGGSDCPDKKKDLFLDMMGDVLFAVPSVIVARYHRDARA 440

  Fly   442 TPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPLLFPDFQRNSTEAKVIHS- 505
            |   .|:|.|.|..  |:.|......|...:|    |::..::.:|.|    :..::|.::..|
  Rat   441 T---TYVYEFKYHP--SFVSDMRPKTVIADHG----DEVYSVWGTPFL----KEGASEEEINLST 492

  Fly   506 -FVDYFVHFAKFGKPR-----------NSESLTPCSIEVLQSRPDGICDYHEFANAPDAYQGFEV 558
             .:.::.:||:.|.|.           ..||.......:.|::.   ..|.|.| .....:|.||
  Rat   493 MMMKFWGNFARNGNPNGEGLPHWPEYDEKESYLQIGTTIQQAQK---LKYKEVA-FWTGLRGMEV 553

  Fly   559 HVASEFQTDR 568
            ..|:|..|.:
  Rat   554 EEATEEDTQK 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	149/548 (27%)
Ces1a	NP_001177304.1	COesterase	24..545	CDD:278561	155/574 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336412
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850