DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhe and Bche

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_075231.1	Gene:	Bche / 65036	RGDID:	619996	Length:	597	Species:	Rattus norvegicus

Alignment Length:	518	Identity:	153/518 - (29%)
Similarity:	233/518 - (44%)	Gaps:	111/518 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 AFMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDCIQK-NYLLP--------TPVVYGDED 112
            ||:|||||.||:|.|||..|:.:.|...:|:|:.....|.|. :...|        .|.....||
  Rat    50 AFLGIPYAQPPLGSLRFKKPQPLNKWPDVYNATKYANSCYQNIDQAFPGFQGSEMWNPNTNLSED 114

  Fly   113 CLYLNVYRPEIRKSALPVMVYIHGGGFFGGSAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLS- 176
            ||||||:.|..:.....|||:::||||..|::...|...::......||:|:|.||:|..|||:
  Rat   115 CLYLNVWIPVPKPKNATVMVWVYGGGFQTGTSSLPVYDGKFLTRVERVIVVSMNYRVGALGFLAF 179

  Fly   177 TQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVI 241
            ..::...||.||.||.|||:|:||||..|||:|:.||:||:|||..:..:|||.|:|:.||.|.|
  Rat   180 PGNSEAPGNMGLFDQQLALQWIQRNIAAFGGNPKSVTLFGESAGAASVSLHLLCPQSYPLFTRAI 244

  Fly   242 SMSGTANVPFAIAEQPLEQAR----LLAEF--ADVPDARNLSTVKLTKALRRINAT-KLLNAGDG 299
            ..||::|.|:|: :.| |:||    .||:|  ....:.:.:.|...:|..:.|... ||:...|.
  Rat   245 LESGSSNAPWAV-KHP-EEARNRTLTLAKFIGCSKENEKEIITCLRSKDPQEILLNEKLVLPSDS 307

  Fly   300 LKYWDVDHMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNET 364
            ::      ..||.|.|:     ..||...|..:|..|...:..:|:|....||..
  Rat   308 IR------SINFGPTVD-----GDFLTDMPHTLLQLGKVKTAQILVGVNKDEGTA---------- 351

  Fly   365 LRQSFNLRFDELLQELLEFPA-SFSQD------RREKMMDLLVEVYFQGQHEVN----------- 411
                           .|.:.| .||:|      |||....|  .:||.|...:.
  Rat   352 ---------------FLVYGAPGFSKDNDSLITRREFQEGL--NMYFPGVSSLGKEAILFYYVDW 399

  Fly   412 ------ELTVQGFMNLISDRGFKQPLYNTI------HKNVCHTPNPVYLYSFNYQGPLSYASAYT 464
                  |:..:.|.::|.|       ||.|      .|.........:.|.|.::
  Rat   400 LGDQTPEVYREAFDDIIGD-------YNIICPALEFTKKFAELEINAFFYYFEHR---------- 447

  Fly   465 SANVTGK--YGVVHCDDLLYLFRSPLLFPDFQRNSTEAKVI--HSFVDYFVHFAKFGKPRNSE 523
            |:.:...  .||:|..::.::|..||   :.:.|.|.|:.|  .|.:..:.:|||:|.|..::
  Rat   448 SSKLPWPEWMGVMHGYEIEFVFGLPL---ERRVNYTRAEEIFSRSIMKTWANFAKYGHPNGTQ 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	153/518 (30%)
Bche	NP_075231.1	COesterase	21..545	CDD:278561	153/518 (30%)
		Aes	<120..>272	CDD:223730	66/153 (43%)
		AChE_tetra	560..594	CDD:285837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910