DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhe and NLGN4X

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	XP_005274621.1	Gene:	NLGN4X / 57502	HGNCID:	14287	Length:	836	Species:	Homo sapiens

Alignment Length:	590	Identity:	162/590 - (27%)
Similarity:	251/590 - (42%)	Gaps:	105/590 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 EAFMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDCIQK-------NYLLP---------- 103
            |.::|:|||.||.|:.||..|:......|:.:.:.....|.|.       :.:||
Human    71 EQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTL 135

  Fly   104 -TPVVYGDEDCLYLNVYRP-----EIRKSA--------------------LPVMVYIHGGGFFGG 142
             |.|...:|||||||:|.|     ..:|:|                    .|||||||||.:..|
Human   136 MTYVQDQNEDCLYLNIYVPTEDGANTKKNADDITSNDRGEDEDIHDQNSKKPVMVYIHGGSYMEG 200

  Fly   143 SAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGG 207
            : |..:.| ......|.||::|:.||||..|||||.|....||:||.||..||||::.|:..|||
Human   201 T-GNMIDG-SILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGG 263

  Fly   208 DPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLAEFADVPD 272
            ||:||||||..||.....:..||..|.|||.:.|..||||...:|:..||.:..|:|   ||...
Human   264 DPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRIL---ADKVG 325

  Fly   273 ARNLSTVKLTKALRRINATKLLNAGDGLKYWDVDHMTNFRPVVEEGLEVDAFLNAHPMDMLAQGM 337
            ...|.|..:.:.||..|..:|:..    ......:...|.||::..:..|     .|..::.||.
Human   326 CNMLDTTDMVECLRNKNYKELIQQ----TITPATYHIAFGPVIDGDVIPD-----DPQILMEQGE 381

  Fly   338 PTSIPLLLGTVPGEGAVRVVNILGNE--TLRQSFNLRFDELLQELLEFPASFSQDRREKMMDLLV 400
            ..:..::||...|||...|..|:.||  .....|:......:..|..:|     :.::.:.:.:.
Human   382 FLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYP-----EGKDTLRETIK 441

  Fly   401 EVYFQGQHEVN-ELTVQGFMNLISDRGFKQPLYNT--IHKNVCHTPNPVYLYSFNYQGPLSYASA 462
            .:|.....:.| |...:..:.|.:|..:..|...|  :|   ....:|.|.|:|.:........:
Human   442 FMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLH---AQYGSPTYFYAFYHHCQSEMKPS 503

  Fly   463 YTSANVTGKYGVVHCDDLLYLFRSPLLFP------DFQRNSTEAKVIHSFVDYFVHFAKFGKPRN 521
            :..:        .|.|::.|:|..|::.|      :|.:|......:  .:.|:.:|||.|.|..
Human   504 WADS--------AHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAV--VMTYWTNFAKTGDPNQ 558

  Fly   522 SESLTPCSIEVLQSRPDGICDYHEFA----NAPD---AYQGFEVHVASEFQTDRVNLW------S 573
            .   .|...:.:.::|:   .:.|.|    |..|   .:.|.:..|...::..:|..|      .
Human   559 P---VPQDTKFIHTKPN---RFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHL 617

  Fly   574 HILNE 578
            |.|||
Human   618 HNLNE 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	148/524 (28%)
NLGN4X	XP_005274621.1	COesterase	42..610	CDD:278561	157/576 (27%)
NLGN4X	XP_005274621.1	Aes	<179..>286	CDD:223730	50/108 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142741
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740