DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhe and ces2a

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001070720.1	Gene:	ces2a / 566132	ZFINID:	ZDB-GENE-061013-99	Length:	555	Species:	Danio rerio

Alignment Length:	556	Identity:	156/556 - (28%)
Similarity:	236/556 - (42%)	Gaps:	120/556 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 CAALATVDQLTVCPPS--VGCLKGTNLQG-YQSER-----FEAFMGIPYALPPIGDLRFSNPKVM 79
            |..||.|....|...|  |..||..:::| |...:     .|.::|||:|.||:|..|.:.|:.:
Zfish    10 CLTLAPVWSAPVQEDSGPVAVLKHGSVRGQYVKAKGSPAVVEQYLGIPFAQPPVGPHRLAAPQPV 74

  Fly    80 PKLLGMYDASAPKMDCIQKNYLLP---------TPVVYGDEDCLYLNVYRPEIRKSA--LPVMVY 133
            ....|:.:|:...:.|:|...:||         ...:...|||||||||.|..|..:  ||||::
Zfish    75 QGWEGIRNATEHPLMCLQNPDILPAIAKAIDLEVTAIGVSEDCLYLNVYTPSQRAESEKLPVMIW 139

  Fly   134 IHGGGFFGGSA----------GPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGL 188
            |||||...|.|          |..:...|      :|::|.:.||||..|:.||.|....||:|.
Zfish   140 IHGGGLAMGGACMFKELCLYDGTPLAAYE------KVVVVVIQYRLGILGYFSTGDQHAKGNWGF 198

  Fly   189 KDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAI 253
            .||..||:|||:||..||||||.|||.|:||||::|.:..|||.:.|||.|.|..||.|.|....
Zfish   199 LDQIAALQWVQQNIEAFGGDPQSVTIAGESAGGISASLLTLSPMTKGLFQRAIFQSGVATVKGYF 263

  Fly   254 AEQPLEQARLLAEFADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVDHMTNFRPVVEEG 318
            .:.|...|:::   |::.:....|:..|.|.:|.:...:::.|..             :..:..|
Zfish   264 VKDPSTHAQVI---ANITECDFSSSEVLVKCIREMTEEQIIKAAQ-------------KKGIFPG 312

  Fly   319 LEVDA-FLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNETLRQSFNLRFDELLQELLE 382
            ..||. |:.|.|.::|.......:|:|:||.                     |..|..:|
Zfish   313 AAVDGEFIKAQPEEILKSKDFQKVPILIGTT---------------------NHEFGWML----- 351

  Fly   383 FPASFSQDRREKMMD---------------------LLVEVYFQGQHEVNELTVQGFMNLISDRG 426
             |..|......|.||                     ::.:.||:......|:. ..|..|:.|..
Zfish   352 -PQIFLPKEWVKGMDTKAAKDRLGLLNADGASGANGIIADEYFKNAKTPEEIR-DAFTELLGDIF 414

  Fly   427 FKQPLYN--TIHKNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPLL 489
            ...|...  :.|:   ....|||:|.|.: || |.|:.:..:.|...    |.||:.::|.:  .
Zfish   415 MVIPSITVASYHR---EAGVPVYMYEFQH-GP-STANKFRPSFVKAD----HADDVGFVFGA--C 468

  Fly   490 FPDFQ------RNSTEAKVIHSFVDYFVHFAKFGKP 519
            |.|..      ....|.::..:.:.|..:|.:.|.|
Zfish   469 FWDVHVKGLGTLTEEENQLCRTVMKYRANFIRTGSP 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	149/537 (28%)
ces2a	NP_001070720.1	COesterase	21..541	CDD:278561	152/545 (28%)
ces2a	NP_001070720.1	Aes	<122..346	CDD:223730	86/266 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575328
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.940