DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhe and nlgn3a

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	XP_005157256.1	Gene:	nlgn3a / 562702	ZFINID:	ZDB-GENE-071219-1	Length:	878	Species:	Danio rerio

Alignment Length:	604	Identity:	158/604 - (26%)
Similarity:	259/604 - (42%)	Gaps:	125/604 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 EAFMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDCIQKNY-----------------LLP 103
            :.::|:|||.||:|:.||..|:......|:.:|:.....|.|..:                 ::.
Zfish    94 DQYLGVPYATPPVGEKRFLPPEPPSSWSGIKNATHFAPVCPQNIHNAVPEIMMPIWFTFNLDIVA 158

  Fly   104 TPVVYGDEDCLYLNVYRP-------------------------------------------EIRK 125
            |.:...:|||||||:|.|                                           :||.
Zfish   159 TSIQDQNEDCLYLNIYVPTEDVKRISKECTRKPNKKICRKGGTHSKKQGEDLSDNDGDEDEDIRD 223

  Fly   126 S-ALPVMVYIHGGGFFGGSAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLK 189
            : |.|||||||||.:..|: |..:.| ......|.||::|:.:|:|..|||||.|....||:||.
Zfish   224 TGAKPVMVYIHGGSYMEGT-GNMIDG-SVLASYGNVIVITLNFRVGVLGFLSTGDQAAKGNYGLL 286

  Fly   190 DQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIA 254
            ||..||||:..||.:||||..|:|:||...|.....:..||..|.|||||.|..||:|...:|:.
Zfish   287 DQIQALRWISENIGYFGGDSNRITVFGSGIGASCVSLLTLSHHSEGLFHRAIIQSGSALSSWAVN 351

  Fly   255 EQPLEQARLLAEFADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVD----HMTNFRPVV 315
            .||::..|||||..   ....|.|:.:...||:.:|.:|:..       |:.    |:. |.||:
Zfish   352 YQPVKYTRLLAEKV---GCNVLDTLDMVDCLRKKSARELVEQ-------DIQPARYHVA-FGPVI 405

  Fly   316 EEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNE--TLRQSFNLRFDELLQ 378
            :..:..|     .|..::.||...:..::||...|||...|.|::.:|  .....|:....:.:.
Zfish   406 DGDVIPD-----DPEILMEQGEFLNYDIMLGVNQGEGLRFVENVVDSEDGVSGNDFDFSVSDFVD 465

  Fly   379 ELLEFPASFSQDRREKMMDLLVEVYFQGQHEVN-ELTVQGFMNLISDRGFKQPLYNT--IHKNVC 440
            .|..:|     :.::.:.:.:..:|.......| |...:..:.|.:|..:.:|...|  :|   .
Zfish   466 SLYGYP-----EGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLH---A 522

  Fly   441 HTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPL-----LFP-DFQRNSTE 499
            ...:|.|.|:|.:........|::.|        .|.|::.|:|..|:     ||| :|.:|...
Zfish   523 RYGSPTYFYAFYHHCQSLMKPAWSDA--------AHGDEVPYVFGIPMIGPTDLFPCNFSKNDIM 579

  Fly   500 AKVIHSFVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICDYHEFA----NAPD---AYQGFE 557
            ...:  .:.|:.:|||.|.|...   .|...:.:.::.:   .:.|.|    |..|   .:.|.:
Zfish   580 LSAV--VMTYWTNFAKTGDPNKP---VPQDTKFIHTKAN---RFEEVAWSKYNPQDQLYLHIGLK 636

  Fly   558 VHVASEFQTDRVNLWSHIL 576
            ..|...::..:|..|.|::
Zfish   637 PRVRDHYRATKVAFWKHLV 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	148/546 (27%)
nlgn3a	XP_005157256.1	COesterase	69..651	CDD:306613	156/598 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575368
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840