DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhe and Ces2h

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001037723.1	Gene:	Ces2h / 498940	RGDID:	1560889	Length:	558	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	169/552 - (30%)
Similarity:	245/552 - (44%)	Gaps:	92/552 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 AFMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDCIQ----------KNYLLPTPVVYGDE 111
            :|:|||:|.||||.|||:.|:......|:.|.::....|:|          |...|..|::...|
  Rat    56 SFLGIPFAKPPIGPLRFAPPEAPEPWSGVRDGTSHPAMCLQDITAMNMQAFKLLKLTLPLIPMSE 120

  Fly   112 DCLYLNVYRPE--IRKSALPVMVYIHGGGFFGGSA----GPGVTGPEYFMDSGEVILVTMAYRLG 170
            ||||||:|.|.  ...|.|||||:||||....|.|    |..:...|      .|::||:.||||
  Rat   121 DCLYLNIYTPNHAHEGSNLPVMVWIHGGALVIGMASLYDGSMLAAME------NVVVVTIQYRLG 179

  Fly   171 PFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHG 235
            ..||.||.|....||:|..||..||.|||:||..|||:|.||||||:||||.:...|::||.|.|
  Rat   180 VLGFFSTGDQHARGNWGYLDQVAALHWVQQNIAHFGGNPDRVTIFGESAGGTSVSSHVVSPMSRG 244

  Fly   236 LFHRVISMSGTANVPFAIAEQPLEQARLLAEFADVPDARNLSTVKLTKALRRINATKLLNAGDGL 300
            |||..|..||.|               |::....|.......||.......::::..|:|...|.
  Rat   245 LFHGAIMESGVA---------------LMSSLISVSSDVVYRTVANLSGCEQVDSKALVNCLRGK 294

  Fly   301 KYWDVDHMTN-FRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGE-GAVRVVNILGNE 363
            ...::..:.. ||  :..|:....||..||.::||......||.::|....| |.:    |..:.
  Rat   295 SEEEIMSINKAFR--IISGIVDGIFLPRHPKELLASADFHPIPSIIGVNNDEYGWI----IPSSM 353

  Fly   364 TLRQSFNLRFDELLQELLE-------FPASFSQDRREKMMDLLVEVYFQGQHEVNELTVQGFMNL 421
            |...|......:::|.:|:       :|..||        |||:|.|.....:...|.|| |..:
  Rat   354 TTTDSKKKMDRQMVQAILQKRVAQMMWPPEFS--------DLLLEEYMGDSEDPQFLQVQ-FKEM 409

  Fly   422 ISDRGFKQPLYNTIHKNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRS 486
            :.|..|..|.....|..  .:..|||.|.|.::.  |:.......:|...:|    |::|::|||
  Rat   410 MEDFTFVIPALQVAHFQ--RSNAPVYFYEFQHRP--SFFKDSKPPHVKADHG----DEILFIFRS 466

  Fly   487 PLLFPDFQRNSTEAKVIHS--FVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICDYHEFANA 549
              .:...|.:.||.:.:.|  .:.|:.:||:.|.| |||.|                .|....:.
  Rat   467 --FWGGTQVDLTEEEELLSRRMMKYWANFARQGNP-NSEGL----------------PYWPVFDH 512

  Fly   550 PDAYQGFEVH--VASEFQTDRVNLWSHILNEK 579
            .:.|...:..  |....:..|:..|:..|.||
  Rat   513 DEQYLQLDTQPAVGRALKAKRLQFWTKTLPEK 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	161/496 (32%)
Ces2h	NP_001037723.1	COesterase	30..537	CDD:278561	165/543 (30%)
Ces2h	NP_001037723.1	Aes	<127..>230	CDD:223730	52/108 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336405
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840