DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhe and ACHE

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001354847.1	Gene:	ACHE / 43	HGNCID:	108	Length:	681	Species:	Homo sapiens

Alignment Length:	581	Identity:	174/581 - (29%)
Similarity:	246/581 - (42%)	Gaps:	146/581 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 MLQLLLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKGTNLQGYQSER----FEAFMGIPYALP 66
            :|.|.|||..:...|...|.|...            ::|..|:|.:.:.    ..||:|||:|.|
Human    86 LLLLWLLGGGVGAEGREDAELLVT------------VRGGRLRGIRLKTPGGPVSAFLGIPFAEP 138

  Fly    67 PIGDLRFSNPKVMPKLLGMYDASAPKMDCIQ-KNYLLP--------TPVVYGDEDCLYLNVYRPE 122
            |:|..||..|:......|:.||:..:..|.| .:.|.|        .|.....||||||||:.|.
Human   139 PMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPY 203

  Fly   123 IR-KSALPVMVYIHGGGFFGGSAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLS---TQDAVMS 183
            .| .|..||:|:|:||||:.|::...|....:.:.:...:||:|.||:|.||||:   :::|  .
Human   204 PRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREA--P 266

  Fly   184 GNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTAN 248
            ||.||.||.|||:|||.|:..|||||..||:||:|||..:..||||||.|.|||||.:..||..|
Human   267 GNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPN 331

  Fly   249 VPFAIAEQPLEQARLLAEFADV----PDARNLSTVKLTKALRRINATKLLNAGDGLKYWDV---- 305
            .|:|..... |..|...:.|.:    |.....:..:|...||...|..|:|     ..|.|
Human   332 GPWATVGMG-EARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVN-----HEWHVLPQE 390

  Fly   306 -DHMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILG-------N 362
             ....:|.|||:     ..||:..|..::..|....:.:|:|.|..||:..:|  .|       |
Human   391 SVFRFSFVPVVD-----GDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLV--YGAPGFSKDN 448

  Fly   363 ETL--RQSFNL-------RFDELLQELL----------EFPASFSQDRREKMMDLLVEVYFQGQH 408
            |:|  |..|..       :..:|..|.:          |.||..    ||.:.|::      |.|
Human   449 ESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARL----REALSDVV------GDH 503

  Fly   409 EV--------NELTVQGFMNLISDRGFKQPLYNTIHKNVCHTPNPVYLYSFNYQG-----PLSYA 460
            .|        ..|..||..                          ||.|.|.::.     ||
Human   504 NVVCPVAQLAGRLAAQGAR--------------------------VYAYVFEHRASTLSWPL--- 539

  Fly   461 SAYTSANVTGKYGVVHCDDLLYLFRSPLLFPDFQRNST-EAKVI-HSFVDYFVHFAKFGKP 519
                      ..||.|..::.::|..||   |..||.| |.|:. ...:.|:.:||:.|.|
Human   540 ----------WMGVPHGYEIEFIFGIPL---DPSRNYTAEEKIFAQRLMRYWANFARTGDP 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	166/547 (30%)
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	168/563 (30%)
ACHE	NP_001354847.1	AChE_tetra	645..678	CDD:400834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142734
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940