Protein Alignment Jhe and Nlg4

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Alignment Length: 728
• Identity: 194/728 - (26%)
• Similarity: 290/728 - (39%)
• Gaps: 202/728 - (27%)

  Fly     8 QLLLLGQLLAGPGPF-----CAALATVDQL-------TVCPPSVGCLKGTNLQGYQSERF----E 56
            |||||.:||..|...     ||..:|.|..       .:.....|.|.|..|. ..|.||    |
  Fly     5 QLLLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILP-LDSFRFLRSVE 68

  Fly    57 AFMGIPYALPPIGDLRFSN--------------------PKVMPKLLGMYDASAPKMDCIQKNY- 100
            .|:|:|||.||....|||.                    |:.:|.:.. ..|:..||...:..|
  Fly    69 VFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQN-ETAALEKMPKGRLEYL 132

  Fly   101 --LLPTPVVYGDEDCLYLNVYRP---EIRKSALPVMVYIHGGGFFGGSAGP--GVTGPEYFMDSG 158
              |||. :....||||||||:.|   ...:..|||:|:|||..|...|..|  |.....|    |
  Fly   133 KRLLPF-LENQSEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASY----G 192

  Fly   159 EVILVTMAYRLGPFGFLSTQD----AVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSA 219
            ||::||:.||||..|||:...    .....|:||.||..||.|:|:||:.|||||..||:.|...
  Fly   193 EVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGT 257

  Fly   220 GGVAAHMHLLSPRS-HGLFHRVISMSGTANVPFAIAEQPLEQARLLAEFAD--VPDARNLSTVKL 281
            |....:..:.||.. .|||||.|.|||:|...:|:.|.|:..|..||:..:  :||..|....::
  Fly   258 GAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQI 322

  Fly   282 TKALRRINATKLLNAGDGLKYWDV---DHMTNFRPVVE--------EGLEVDAFLNAHPMDMLAQ 335
            ...||.:....|..|       |:   :.:|:|.|.|:        ..|::|        |::|:
  Fly   323 VDCLRDVPLEDLYLA-------DIQAPNFLTSFGPSVDGVVIRPGHSNLDID--------DLMAR 372

  Fly   336 ---------GMPTSIPLLLGTVPGEG-----------------------AVRVVNILGNETLRQS 368
                     |..:|    .|...|:|                       ....:|:.|:
  Fly   373 NSRRSSADSGFQSS----AGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGH------ 427

  Fly   369 FNLRFDELL-----QELLEFPA-----SFSQDRREKMMDLLV---------EVYF---------- 404
                :|.|.     :.:..|.|     .|..:||:|::...|         |:::
  Fly   428 ----YDVLFGVVTGESIWRFSAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTDWD 488

  Fly   405 -QGQHEVNELTVQGFMNLISDRGFKQPLYNTIHKNVCHTPNPVYLYSFNYQGPLSYASAYTSANV 468
             ..||.:|  |....:..:||..|..|:.........::|.|| ..|.....|.:.|:|.|||..
  Fly   489 RTSQHPIN--TRDTAVAALSDAQFVAPIVRAGDILAANSPPPV-SSSSTAGSPGANAAASTSAGS 550

  Fly   469 T-----------------GKY----GVVHCDDLLYLFRSPLL--FPDFQRNST--EAKVIHSFVD 508
            |                 |.|    |.||.:||.|:|.:||:  |..|.:|.|  |..:..:.:.
  Fly   551 TQPSGRCYFYVFDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMI 615

  Fly   509 YFVHFAKFGKP---RNSESLTPCSIEVLQSRPDGICDYHEFANAPDAYQ-----GFEVHVASEFQ 565
            ::.:||:.|.|   ...:|..|.|.|  ::|...|    .:.|....:|     |.:..:.:.|:
  Fly   616 FWTNFARTGNPNEHHRQDSSLPVSKE--RNRFRSI----TWENYDPLHQKYLEIGMKPRIKNHFR 674

  Fly   566 TDRVNLWSHILNE 578
            ..::::|..::.|
  Fly   675 AHQLSIWLRLIPE 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	171/628 (27%)
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	180/682 (26%)