Protein Alignment Jhe and Nlg3

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Alignment Length: 684
• Identity: 175/684 - (25%)
• Similarity: 268/684 - (39%)
• Gaps: 198/684 - (28%)

  Fly    40 GCLKG--TNLQGYQSERFEAFMGIPYALPPIGDLRFSNP----------------KVMP-KLLGM 85
            |.:.|  ..|.|...:..||:.|||||.||:|:|||..|                .|.| :|..:
  Fly   163 GAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCPQRLPDI 227

  Fly    86 YDASA-----PKMDCIQKNYLLPTPVVYGDEDCLYLNVYRP-----------EIRKSA------- 127
            ::.:|     ||........|||. :....|||||||:|.|           ....||
  Fly   228 HNETAALERMPKGRLEYLKRLLPY-LQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSSAGSSSSGS 291

  Fly   128 ------------------------LPVMVYIHGGGFFGGSAGP--GVTGPEYFMDSGEVILVTMA 166
                                    .||:|::||..:...|..|  |.....|    |::::||:.
  Fly   292 GGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASY----GQILVVTIN 352

  Fly   167 YRLGPFGFLSTQD---AVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHL 228
            ||||..|||:...   :.:..|:||.|...||.|::.||..|||||..:|:.|...|....|. |
  Fly   353 YRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAACVHF-L 416

  Fly   229 LSPRS--HG-LFHRVISMSGTANVPFAIAEQPLEQARLLAEF----ADVPDARNLSTVKLTKALR 286
            :|..:  .| ||:|.|.|||:...|:::...|.:.|.::|..    :|:|.|.      |.|.||
  Fly   417 ISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAH------LMKCLR 475

  Fly   287 RINATKLLNAGDGLKYWDVDHMTNFRPVVEEGLEVDA--FLNAHPMDMLAQGMPTSIPLLLGTVP 349
            .....:||:    :.....:....|.|.: :|:.:|.  ::...|....||....:     .|..
  Fly   476 EKTLDQLLS----VPIRPPEFGFAFGPSI-DGVVIDGGDYVPPAPGSPAAQAQAQA-----STAA 530

  Fly   350 GEGAVRVVNILGNE----------TLRQSFNL------------RFDELLQELLEFPASFS---- 388
            |.|       ||.|          |..|..|:            |:| |:..:....|.||
  Fly   531 GNG-------LGGEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYD-LMAGVTRAEAFFSFNSG 587

  Fly   389 -------QDRREKMMDLLV-EVYFQGQHE-----VNELT-----VQGFMNL-------ISDRGFK 428
                   .|||.:::...| ..|....:|     |||.|     ||..:|:       :||....
  Fly   588 DVQYGIEADRRSRILKAYVRNTYTFHLNEIFATIVNEYTDWERPVQHPINIRDETLEALSDAQVV 652

  Fly   429 QPLYNTI------HKNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKY----GVVHCDDLLYL 483
            .|...|:      |:|       .|||.|:||...            |.|    |.:|.:||.|:
  Fly   653 APAAQTVDLHSADHRN-------SYLYVFDYQTRF------------GDYPQRQGCIHGEDLPYI 698

  Fly   484 FRSPLL--FPDFQRNSTEAKVIHSFV--DYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICDYH 544
            |.:||:  |..|.||.|:.::..|.|  .|:.:|.:.|.| |.:..|.......:||...| ::.
  Fly   699 FGAPLVGGFNHFTRNYTKTEISLSEVVMFYWSNFVRTGNP-NEQMETEHGSRQERSRYKTI-EWT 761

  Fly   545 EFANAPDAYQGFEV--HVASEFQTDRVNLWSHIL 576
            .:.:....|..|:.  .:.:.::..|::.|.:::
  Fly   762 AYESVHKKYLNFDTKPKLKNHYRAHRLSFWLNLI 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	167/631 (26%)
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	174/678 (26%)