DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhe and alpha-Est6

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	613	Identity:	175/613 - (28%)
Similarity:	259/613 - (42%)	Gaps:	135/613 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 CAALATVDQLTVCPPSVGCLKGTNLQGYQSERFEAFMGIPYALPPIGDLRFSNPKVMPKLLGMYD 87
            |.:....|. .|...|||.:||..|.|...:.|.:|.|||:|.||:|..||    |..:|...::
  Fly    32 CQSAGDADS-KVVKLSVGSVKGRRLSGIYGDEFYSFEGIPFAKPPLGKARF----VASQLADPWN 91

  Fly    88 ASAPKMDCIQKNYLLPTPV--------VYGDEDCLYLNVYRPEIRKS--ALPVMVYIHGGGFFGG 142
            :   ::|..|:.   |.|:        |.|.|||||||||.....:|  .|||||||:||.|..|
  Fly    92 S---ELDARQER---PIPLQMDRRSGKVVGSEDCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTG 150

  Fly   143 SAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMS--GNFGLKDQNLALRWVQRNIRFF 205
            .|.....||:|.| |.:|:.|...|||...||||.....:.  ||.||.||.|||:||.::||.|
  Fly   151 GAVKSKYGPDYLM-SRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNF 214

  Fly   206 GGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLAEFADV 270
            .||||.:|:||:|||..:.|..:..|::.||||:.|.|||:                :|:.:.:.
  Fly   215 NGDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGS----------------MLSPWVNA 263

  Fly   271 PDARNL--------------STVKLTKALRRINATKLLNAGDGLKYWD--VDHMTNFRPVVEEGL 319
            ||:..:              ..|.:.:.||.:||.||: ..|.:...|  ...:..|.||| .||
  Fly   264 PDSDGIFCRLATSAGYEGPAEEVPILEFLRNVNAEKLI-GHDFISPRDRCFGFLNPFAPVV-GGL 326

  Fly   320 EVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAV----------RVVNILGNETLRQSFNLRFD 374
            ....|     ..::.:.....:|||||....||.|          .::.:|.:|...
  Fly   327 VAAPF-----QQLMKEAWSCEVPLLLGGTSFEGLVYYPFCQLDNGYMLELLKHEPAM-------- 378

  Fly   375 ELLQELLEFPASFSQDRREKMMDLLVEVYFQGQHEVNELTVQGFMNLISDRGFKQPLYNTIHKNV 439
            .|..||.:   |.|.:.|....|:||: |..|...:.:..:...::|.|.:.|...::..:...:
  Fly   379 VLPHELYQ---SMSVEERNTAADVLVK-YHYGPRGITKSNITQILDLFSYKLFWHGIHRVVLSRL 439

  Fly   440 CHTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLF------RSPLLFPDFQRNST 498
            .|...|.|||.|::..|..............|.||.|.|||.|:|      :.||..|:|
  Fly   440 SHAQAPTYLYRFDFDSPKLNLMRNQLCGDDIKRGVCHADDLGYIFHKQAQAKQPLDSPEF----- 499

  Fly   499 EAKVIHSFVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICDYHEFANAPDAYQ--------- 554
              ..|...|.....||:.|.|...|:                        .||.:.
  Fly   500 --LTIQRMVGILTTFARTGDPNCPET------------------------GPDPWMPVSTKSPFK 538

  Fly   555 ----GFEVHVASEFQTDRVNLWSHILNE 578
                |.:|...::.:.|.:.:|:.:.::
  Fly   539 ALNIGQQVECVTQVEKDGLKVWNRLYSD 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	164/530 (31%)
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	170/576 (30%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	76/210 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440415
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.800