DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhe and alpha-Est10

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	183/563 - (32%)
Similarity:	253/563 - (44%)	Gaps:	89/563 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GCLKGTNLQGYQSERFEAFMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDCIQ-----KN 99
            |.::|..........:.:|..||:|.||:|||||..|:.:.......|.::|....:|     :.
  Fly    56 GPVRGVKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPLQTHMFFRK 120

  Fly   100 YLLPTPVVYGDEDCLYLNVYRPEIRKSAL-PVMVYIHGGGFFGGSAGPGVTGPEYFMDSGEVILV 163
            |.       |.|||||||||..:::...| ||||:|:|||:..|.|...:..|::|| |.:|::|
  Fly   121 YA-------GSEDCLYLNVYVKDLQPDKLRPVMVWIYGGGYQVGEASRDMYSPDFFM-SKDVVIV 177

  Fly   164 TMAYRLGPFGFLSTQDAVMS--GNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHM 226
            |:|||||..||||..|..::  ||.|||||.:||||||:||..||||...:|:||:||||.:.|.
  Fly   178 TVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGGASTHF 242

  Fly   227 HLLSPRSHGLFHRVISMSGTANVPFAIAEQP------LEQARLLAEFADVPD------ARNLSTV 279
            ..|||::.||.|:.|.|||:...|:.   ||      ...|:.|....|..|      .|::|..
  Fly   243 LALSPQTEGLIHKAIVMSGSVLCPWT---QPPRNNWAYRLAQKLGYTGDNKDKAIFEFLRSMSGG 304

  Fly   280 KLTKALRRINATKLLNAGDGLKYWDVDH---MTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPTSI 341
            ::.||    .||.|.|        |..|   :..|.||||........:...|.:::.......|
  Fly   305 EIVKA----TATVLSN--------DEKHHRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWSHRI 357

  Fly   342 PLLLGTVPGEGAV---------RVVNILGN--ETLRQSFNLRFDELLQELLEFPASFSQDRREKM 395
            |::.|....||.:         ..::.:||  ..|.....|..|..|              ||..
  Fly   358 PMMFGGTSFEGLLFYPEVSRRPATLDEVGNCKNLLPSDLGLNLDPKL--------------RENY 408

  Fly   396 MDLLVEVYFQGQHEVNELTVQGFMNLISDRGFKQPLYNTIHKNVCHTPNPVYLYSFNYQGPLSYA 460
            ...|.:.|| |....|:..:..|:.|.|.|.|..|:|......|..:..|.|||.|::...|..|
  Fly   409 GLQLKKAYF-GDEPCNQANMMKFLELCSYREFWHPIYRAALNRVRQSSAPTYLYRFDHDSKLCNA 472

  Fly   461 SAYTSANVTGKYGVVHCDDLLYLFRSPLLF---PDFQRNSTEAKVIHSFVDYFVHFAKFGKPRNS 522
            ..........: ||.|.|||.|:|.|.|..   ||    |.|.|||...||.:..||..|.| |.
  Fly   473 IRIVLCGHQMR-GVCHGDDLCYIFHSMLSHQSAPD----SPEHKVITGMVDVWTSFAAHGDP-NC 531

  Fly   523 ESLTPCSIEVLQSRPDGICDYHEFANAPDAYQGFEVHVASEFQ 565
            ||:.......:::..:..|     .|..|.   |||....|.|
  Fly   532 ESIKSLKFAPIENVTNFKC-----LNIGDQ---FEVMALPELQ 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	175/523 (33%)
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	175/529 (33%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	70/150 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440418
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	7	6.740