DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhe and Est-P

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	582	Identity:	162/582 - (27%)
Similarity:	265/582 - (45%)	Gaps:	73/582 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 IQQRMLQLLLLGQLLAGPGPFCAAL-ATVDQLTVCPPSVGCLKGTN--LQGYQSERFEAFMGIPY 63
            |.:|:|.|.||         :.||| :..|.|.|        :.||  ::|..:..:.::..||.
  Fly     3 IFKRLLCLTLL---------WIAALESEADPLIV--------EITNGKIRGKDNGLYYSYESIPN 50

  Fly    64 ALPPIGDLRFSNPK-VMPKLLGMYDASAPKMDCIQKN-YLLPTPVVYGDEDCLYLNVYRP-EIRK 125
            |..|.|.|||..|: .......:::|:...::|:|.| ::.....:.||||||.:::|:| :..:
  Fly    51 AEHPTGALRFEAPQPYSHHWTDVFNATQSPVECMQWNQFINENNKLMGDEDCLTVSIYKPKKPNR 115

  Fly   126 SALPVMVYIHGGGFFGGSAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKD 190
            |:.||:|.:|||.|..||.  .:.|.:..|..|.:::|.:::.|||.||.||.|..:.||:||||
  Fly   116 SSFPVVVLLHGGAFMFGSG--SIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKD 178

  Fly   191 QNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAE 255
            |.|||:|:::||..|||.|..:.:.|.||||.:||:.||......|....||:||.|..|:.|.:
  Fly   179 QRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQ 243

  Fly   256 QPLEQARLLAEFADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVDHMTNFRPVVEEGLE 320
            ....:|..|......... |:| .:|...|:...|:.:::|......:.....:.|.||||....
  Fly   244 GGRRRAFELGRIVGCGHT-NVS-AELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDA 306

  Fly   321 VDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNIL-GNETLRQSF----NLRFDELLQEL 380
            .||||...|..::..|....:|..:.....:|......:| .|:...:|:    |.|:.:....|
  Fly   307 PDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWIDLLNDRWFDWAPYL 371

  Fly   381 LEFPASFSQDRREKMMDL------LVEVYFQGQHEVNELTVQGFMN---LISDRGFKQPLYNTIH 436
            |     |.:|.::.:.|:      |.:.|...:    ..:|:.:.|   :.:|..||..:.:.|.
  Fly   372 L-----FYRDAKKTIKDMDDLSFDLRQQYLADR----RFSVESYWNVQRMFTDVLFKNSVPSAID 427

  Fly   437 KNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTG-KYGVVHCDDLLYLFRSPL----LFPDFQRN 496
            .:..:..:||  |||.|..|.........:|.|. .:|.||.||...:|.:..    :.||
  Fly   428 LHRKYGKSPV--YSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIFNTAAYRTGIRPD---- 486

  Fly   497 STEAKVIHSFVDYFVHFA-------KFGKPRNSESLTPCSIEVLQ-SRPDGICDYHEFANAP 550
              |..:...|:.....||       .||:.....::.....:||: ||  ..|...|:|..|
  Fly   487 --EEVISKKFIGMLEDFALNDKGTLTFGECNFQNNVNSKEYQVLRISR--NACKNEEYARFP 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	142/517 (27%)
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	148/541 (27%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	57/134 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440343
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.890