Protein Alignment Jhe and Ces3a

DIOPT Version :9

• Sequence 1: NP_001163166.1
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_941074.1
• Gene: Ces3a / 382053
• MGIID: 102773
• Length: 571
• Species: Mus musculus
• Alignment Length: 606
• Identity: 178/606 - (29%)
• Similarity: 248/606 - (40%)
• Gaps: 120/606 - (19%)

  Fly    24 AALATVDQLTVCPPSV---------GCLKGTNLQGYQSERF-EAFMGIPYALPPIGDLRFSNPKV 78
            |.|..:...||..|.|         |.::|..:....::|. ..|:|||:|..|:|.||||.|..
Mouse    19 ACLLLIFPTTVIGPKVTQPEVDTPLGRVRGRQVGVKDTDRMVNVFLGIPFAQAPLGPLRFSAPLP 83

  Fly    79 MPKLLGMYDASAPKMDCIQ--------------KNYLLPTPVVYGDEDCLYLNVYRP-EIRK-SA 127
            .....|:.|||.....|:|              |..:.|.     .||||.||:|.| ||.. ..
Mouse    84 PQPWEGVRDASINPPMCLQDVERMSNSRFTLNEKMKIFPI-----SEDCLTLNIYSPTEITAGDK 143

  Fly   128 LPVMVYIHGGGFFGGSA----GPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGL 188
            .||||:||||....||:    |..:..      .|:|::||:.||||.||||||.|..|.||.|.
Mouse   144 RPVMVWIHGGSLLVGSSTSHDGSALAA------YGDVVVVTVQYRLGIFGFLSTGDKHMPGNRGF 202

  Fly   189 KDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAI 253
            .|...||||||.||..|||||..|||||.||||:.....||||.|.|||||.||.||      .:
Mouse   203 LDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSG------VV 261

  Fly   254 AEQPLEQARLLAE---FADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVDHMTNFRPVV 315
            ..:.||.....:|   ||:.....:.|..:|.:.|.:.....|:..    |..::.:..|
Mouse   262 ISKILEDLNAWSEAQNFANSVACGSASPAELVQCLLQKEGKDLITK----KNVNISYTVN----- 317

  Fly   316 EEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGA---VRVVNILGN-ETLRQSFNLRFDEL 376
                  |:|....|..:||.....::|.|||....|..   ::..|||.. |.|.|...|.....
Mouse   318 ------DSFFPQRPQKLLANKQFPTVPYLLGVTNHEFGWLLLKFWNILDKMEHLSQEDLLENSRP 376

  Fly   377 LQELLEFPASFSQDRREKMMDLLVEVYF-QGQHEVNELTVQGFMNLISDRGFKQPLYNTIHKNVC 440
            |...::.|        .::|..:::.|. .|..|  ..|......|:.|.....|.. ...|.:.
Mouse   377 LLAHMQLP--------PEIMPTVIDEYLDNGSDE--SATRYALQELLGDITLVIPTL-IFSKYLQ 430

  Fly   441 HTPNPVYLYSFNYQGPLSYAS---AYTSANVTGKYGVVHCDDLLYLFRSPLL--------FPDFQ 494
            ....||:||.|.:. |.|:|.   |:..|:        |..:..::|..|.|        ||  :
Mouse   431 DAGCPVFLYEFQHT-PSSFAKFKPAWVKAD--------HSSENAFVFGGPFLTDESSLLAFP--E 484

  Fly   495 RNSTEAKVIHSFVDYFVHFAKFGKPRNSESLTPC-SIEVLQSRPDGICDYHEFANAPDAYQGFEV 558
            ....|.::..:.:..:..||:.|.| |.:.|.|. .:..|:       .|.|.        |.|.
Mouse   485 ATEEEKQLSLTMMAQWSQFARTGNP-NGKGLPPWPQLNQLE-------QYLEI--------GLEP 533

  Fly   559 HVASEFQTDRVNLWSHILNEK 579
            ....:.:..|:..|:..|..|
Mouse   534 RTGVKLKKGRLQFWTETLPRK 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	162/526 (31%)
Ces3a	NP_941074.1	COesterase	36..547	CDD:278561	169/580 (29%)
		Aes	75..>245	CDD:223730	78/180 (43%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832480
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840