DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhe and Gli

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	153/548 - (27%)
Similarity:	226/548 - (41%)	Gaps:	147/548 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 FMGIPYALPPIGDLRFSNPKVMP--KLLGMYDASAPKMDCIQKNYLLPTPVVYG---------DE 111
            |:||||||||..:.||..|:|..  :||...|....   |       |.||.|.         ||
  Fly   178 FLGIPYALPPTFEGRFKPPRVHRGWQLLQAVDFGPA---C-------PQPVRYTGATKGIMDMDE 232

  Fly   112 DCLYLNVYRPEIRKSA---LPVMVYIHGGGFFGGSAG--PGVTGPEYFMDSGEVILVTMAYRLGP 171
            ||||||||.|:.....   .|||||||||.|..|::.  .|.....::    :|::||:.||||.
  Fly   233 DCLYLNVYSPKTGAGVAQKYPVMVYIHGGEFIRGASNLFQGHILASFY----DVVVVTLNYRLGA 293

  Fly   172 FGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGL 236
            .|||||.|....||:|:.||.:|||||..||.||.||...:|:||..|||.:|.:.:::|::..:
  Fly   294 LGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNI 358

  Fly   237 FHRVISMSGTANVPFAIAEQPLEQARLLAEFADVPD---ARNLSTV-------------KLTKAL 285
            ..|||:.||:|                ||::|.:.|   |:|.|.|             ||...|
  Fly   359 VRRVIAQSGSA----------------LADWALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCL 407

  Fly   286 RRINATKLLNAGDGLKYWDVDHMTNFRPVV---------------------EEGLEVD-AFLNAH 328
            |           .|..::::.: ..|.|.|                     |...|.| .||...
  Fly   408 R-----------TGRSFYELGN-AEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQT 460

  Fly   329 PMDMLAQG-MPTSIPLLLGTVPGEGAVRVVNILGNETLRQSFNL--RFDELLQELLEFPASFSQD 390
            |..::..| ...:|..:.|....|.|..|..   ||:|...:.|  ||             |.|.
  Fly   461 PETLIRAGKFNRNIQYMTGVTTQEAAFFVAQ---NESLSPYYELDGRF-------------FDQK 509

  Fly   391 RREKMMDLLVEVYFQGQHEV-------------NELTVQGFMNLISDRGFKQPLYNTIHKNVCHT 442
            .||.:......:...|.:|.             |.:....::|::||..::.|:...: |.:...
  Fly   510 IREHVFRYNYTLNPNGVYEAIKYIYTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMV-KLMLEQ 573

  Fly   443 PNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPLLFPDF-------QRN---S 497
            ..|||:|..|        :...:.|:.......|..:..:|..:|.:..:|       |||   .
  Fly   574 KVPVYMYVLN--------TTVEALNLPQWRKYPHDIERYFLTGAPFMDTEFFPKKEHLQRNMWTD 630

  Fly   498 TEAKVIHSFVDYFVHFAKFGKPRNSESL 525
            .:..:.|.|:..:.:||::|.|...:.|
  Fly   631 NDRNMSHFFMQTYTNFARYGNPTPQQVL 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	153/548 (28%)
Gli	NP_476602.1	COesterase	134..695	CDD:278561	153/548 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440383
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.740