Protein Alignment Jhe and AADACL4

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_001013652.1
• Gene: AADACL4 / 343066
• HGNCID: 32038
• Length: 407
• Species: Homo sapiens
• Alignment Length: 301
• Identity: 67/301 - (22%)
• Similarity: 113/301 - (37%)
• Gaps: 85/301 - (28%)

  Fly    55 FEAFM--GIPYALPPIGDLRFSN-------------PKV----MPKLLG-MYDASAPKMDCIQKN 99
            ||.|:  .||..|.....|||.:             .|:    |||.:. ::|:...|.|    .
Human    25 FEHFLTTDIPATLQHPAKLRFLHCIFLYLVTLGNIFEKLGICSMPKFIRFLHDSVRIKKD----P 85

  Fly   100 YLLPTPVVYGDEDCLYLNVYRPEIRKSALP--VMVYIHGGGFFGGSAG--PGVTGPEYFMDSGEV 160
            .|:.|.:.:|   .:.:.:::|: ..|:.|  .:::.|||....||..  .|:.  .|.....|.
Human    86 ELVVTDLRFG---TIPVRLFQPK-AASSRPRRGIIFYHGGATVFGSLDCYHGLC--NYLARETES 144

  Fly   161 ILVTMAYRL-----GPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAG 220
            :|:.:.||.     .|..|   ||.:          |.::.:: :.:..:|.||.||.:.|:|.|
Human   145 VLLMIGYRKLPDHHSPALF---QDCM----------NASIHFL-KALETYGVDPSRVVVCGESVG 195

  Fly   221 GVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLAEFADVPDARNLSTVKLTKAL 285
            |.|.         ..:...::..|....:...:...|:.||..|    .:|..:....|.|..
Human   196 GAAV---------AAITQALVGRSDLPRIRAQVLIYPVVQAFCL----QLPSFQQNQNVPLLS-- 245

  Fly   286 RRINATKLLNAGDGLKYWDVDHMTNFRPVVEEGLEVDAFLN 326
            |:...|.|.|      |..:|  .::|         ||.||
Human   246 RKFMVTSLCN------YLAID--LSWR---------DAILN 269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	67/301 (22%)
AADACL4	NP_001013652.1	alpha/beta hydrolases	115..378	CDD:473884	45/203 (22%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	119..121		1/1 (100%)