DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhe and CG4382

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster

Alignment Length:	574	Identity:	170/574 - (29%)
Similarity:	257/574 - (44%)	Gaps:	82/574 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VCPPSVGCLKGTNLQGYQSERFEAFMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDCIQK 98
            |...::|.::||.|.......|.||.|||||.||:..|||..|:.:.:.....||:.....|.|.
  Fly    45 VITTALGKIRGTILPSQSGRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQL 109

  Fly    99 NYLLPTPVVYGD--EDCLYLNVY--------RPEIRKSALPVMVYIHGGGFFGGSA-GPGVTGPE 152
            .      :|.||  ||||.:|:|        :|.:|:   ||:|:||.|||:..|. .....||:
  Fly   110 G------LVSGDVSEDCLRVNIYTKELPSESQPNVRR---PVIVFIHPGGFYSLSGQSKNFAGPQ 165

  Fly   153 YFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQ 217
            |||:. .::|||..||||..|||:|......||.|||||...||||:.:|..|||||..:|:.|.
  Fly   166 YFMNR-RLVLVTFNYRLGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGY 229

  Fly   218 SAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLE----QARLLAEFADVPDARNLST 278
            .||.:|..:|::||.|.||||:.|.|||.....:::.:..::    ||.||          :..|
  Fly   230 GAGAMAVTLHMVSPMSRGLFHKAIVMSGAVTGQWSLPDHQMDVATKQATLL----------HCHT 284

  Fly   279 VKLTKALRRINATKLLNAGDGL-KYWDVDH---MTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPT 339
            ..:|:.:..:.....|...:.| |.::.|.   :..::||:|.....:.||...|:.........
  Fly   285 ENVTEMMDCLKGKHYLEFANTLPKMFEFDRNNPLILWKPVIEPDFGQERFLVEEPIRSYQNDDFM 349

  Fly   340 SIPLLLGTVPGEGAVRVVNILGNETLRQSFNLRFDELLQELLEFPAS------FSQD-RREKMMD 397
            .:|::.|....|.....::||.:.||..:.|..|:.|......:..|      .||: |.....|
  Fly   350 KVPIITGMTKDEFVGPALSILQSPTLLSALNENFESLAPVFFMYNTSDARACNISQELRNHYFPD 414

  Fly   398 LLVEVYFQGQHEVNELTVQGFMNLISD--RGFKQPLYNTIHK--NVCHTPNPVYLYSFNYQGPLS 458
            .|::.         ..:::...||.||  .||      .||:  ::......||.|.|:|||..|
  Fly   415 KLIDA---------NRSLEALSNLYSDALTGF------GIHRFVHLAARSTKVYYYRFSYQGARS 464

  Fly   459 YASAYTSANVTGKYGVVHCDDLLYLFRSPLLFPDFQRNSTEAKVIHSFVDYFVHFAKFGKPRNSE 523
            :......|    .|||||.|||:|||..|.:...|..:..|.:::...|..|..||..|.|...
  Fly   465 HIYYPEDA----PYGVVHHDDLMYLFVEPSISRMFTEDDDEFRMVDIMVRMFSAFAYKGDPNKP- 524

  Fly   524 SLTPCSIEVLQSRPDGICDYHEFANAPDAYQGFEVHVASE--FQTDRVNLWSHI 575
              |..::..::.||        |:.....|.....|:..|  ...:...:|..:
  Fly   525 --TDLALRDIRWRP--------FSFKKRYYLDIGKHITLEENLNAENYEIWKRL 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	161/516 (31%)
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	169/569 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440419
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25795
OrthoDB	1	1.010	-	-		D102505at50557
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	11	10.910