DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhe and Glt

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	159/542 - (29%)
Similarity:	246/542 - (45%)	Gaps:	84/542 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ATVDQLTVCPPSVGCLKGTNLQGYQ---SERFEAFMGIPY-----------ALPPIGDLRFSNPK 77
            |...:..|..|.||.:.|  :.|::   :....||:||.|           |..|||
  Fly    55 AQPQEAVVQAPEVGQILG--ISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQPIG-------- 109

  Fly    78 VMPKLLGMYDASAPKMDCIQKNYL--LPTPVVYGD--EDCLYLNVYRPEIRKSALPVMVYIHGGG 138
                ..|..:|:....:|.|...|  |......|:  :|||.|::|.|| ..:.|||:|::||..
  Fly   110 ----YQGRVNATVQSPNCAQFPELDRLRLSESRGENVDDCLTLDIYAPE-GANQLPVLVFVHGEM 169

  Fly   139 FFGGSAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIR 203
            .|.|  |.....|:|.::. :|:||::.|||.||||||.....:.||..|.|..|||.|:|||:.
  Fly   170 LFDG--GSEEAQPDYVLEK-DVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVV 231

  Fly   204 FFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLAEFA 268
            .|||:..:||:.||:.|...||...||.|:..||.::|..||||..|:.|..|||:.....|..|
  Fly   232 HFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLA 296

  Fly   269 DV------PDARNLSTVKLTKALRRINATKLLNAGDGL----KYWDVDHMTNFRPVVEEGLEVDA 323
            ..      |.|:.|.  .|...|.|:..::|:.|.:.|    ::..:..:..|:.||.:.|   .
  Fly   297 RCPPPSINPSAQGLK--PLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPL---G 356

  Fly   324 FLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNETLRQSFNLRFDELLQELLEFPASFS 388
            ||.:||.. ||.....::|:::|......|..|..|.......||.|:  .:.:..:|...|..|
  Fly   357 FLPSHPAS-LATNSSLALPMIIGATKDASAFIVSRIYDQLARLQSRNV--SDYIDVVLRHTAPPS 418

  Fly   389 QDRREKMMDLLVEVYFQGQHEVNEL--TVQGFMNLISDRGFKQPLYNTIHKNVCHTPNPVYLYSF 451
            :.|..|.. .|.|::...|.:...|  ...|.:.|.:...::.|:.|:|.::  :...|.|||:|
  Fly   419 EHRLWKQW-ALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQS--YRSVPAYLYTF 480

  Fly   452 NYQG----------PLSYASAYTSANVTGKYGVVHCDDLLYLFRSPLLFPDFQR-NSTEAKVIHS 505
            :|:|          ||.:.   ..|:::        ||.:|||..|   |:..| |..:..:..:
  Fly   481 DYRGEHHRFGHLSNPLPFG---VDASLS--------DDSVYLFPYP---PEASRLNPLDRSLSRA 531

  Fly   506 FVDYFVHFAKFGKPRNSESLTP 527
            .|..:|:||..|.|..|..:.|
  Fly   532 LVTMWVNFATTGVPNPSSGVWP 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	154/527 (29%)
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	159/542 (29%)
		Aes	<146..345	CDD:223730	75/204 (37%)
		RILP-like	<677..>717	CDD:304877
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440404
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.850