DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhe and Ces5a

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001012056.2	Gene:	Ces5a / 307660	RGDID:	1549717	Length:	575	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	173/571 - (30%)
Similarity:	267/571 - (46%)	Gaps:	108/571 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LQGYQS------ERFEAFMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDCIQ-------- 97
            :||.|:      |....|:|||:|.||:|.||||||:.......:.:|:.....|.|
  Rat    40 VQGKQATVLGRLEPVNVFLGIPFAAPPLGPLRFSNPQPPIPWHDLREATTYPNVCFQNLEWLFIY 104

  Fly    98 KNYL-LPTPVVYGDEDCLYLNVYRPEIRK--SALPVMVYIHGGGFFGGSA----GPGVTGPEYFM 155
            :|.| :..|.:...|||||||:|.|....  |.||||::|.||||..|||    |..:...|
  Rat   105 QNLLKVHYPKLGVSEDCLYLNIYAPAYANDGSRLPVMMWIPGGGFETGSASIFDGSALAAYE--- 166

  Fly   156 DSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAG 220
               :|::||:.||||.|||.:||:....||:..:||..||:||:.||.:|||:|..|||||.|||
  Rat   167 ---DVLIVTIQYRLGIFGFFNTQNQHAPGNWAFQDQLAALQWVRENINYFGGNPDSVTIFGGSAG 228

  Fly   221 GVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLAEFADVPDARNLSTVK-LTKA 284
            .::....:|||.|.|||||.|..||.|.:| ::.....|....|...|||... |:|..| |.|.
  Rat   229 AISISSLILSPLSAGLFHRAIMQSGVAIIP-SLKNFDDELKHGLQVVADVCKC-NVSDSKVLLKC 291

  Fly   285 LRRINATKLLNAGDGLKYWDVDHMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGT-- 347
            ||..::.:||:.|...|        .|..||:     .:|....||::|:|....::|.::|.
  Rat   292 LREKSSLELLSLGQKTK--------AFTRVVD-----GSFFPEEPMELLSQKTFKTVPSIIGVNN 343

  Fly   348 ------VPGEGAVRVVNILG-NETLRQSFNLRFDELLQELLEFPASFSQDRREKMMDLLVEVYFQ 405
                  :|...|..:  :.| ||:...:       |:..||..|..:        |.::.:.||.
  Rat   344 QECGYILPMREAPEI--LFGSNESTALT-------LIHVLLHIPPQY--------MHIVAKDYFH 391

  Fly   406 GQHEVNELTVQGFMNLISDRGFKQPLYNTIHKNVCHTPNPVYLYSFNYQGPLSYAS---AYTSAN 467
            |:|.:.::. ...::|..|..|..|...|. :|......|||.|.|.:: |..:.:   |:..|:
  Rat   392 GKHSLTDIR-DTLLDLFGDVFFVVPGLVTA-RNHRDAGGPVYFYEFQHR-PNCFQNTRPAFVKAD 453

  Fly   468 VTGKYGVVHCDDLLYLFRSPLLFPD---FQRNSTEAKVI-HSFVDYFVHFAKFGKPRNSE-SLTP 527
                    |.|::.::|..|.|..|   |:..:.:.|:: ...:.|:.:||:.|.|...: .|.|
  Rat   454 --------HTDEIRFVFGGPFLEGDVVMFEEATEDEKLLSRKMMSYWANFARSGDPNGDDLPLWP 510

  Fly   528 CSIEVLQSRPDGICDYHEFANAPDAYQGFEVHVAS--EFQTDRVNLWSHIL 576
            .            .|.:|      :|...:|::::  ..:..||..|:..|
  Rat   511 A------------YDQNE------SYLKLDVNISTGWRLKDRRVEFWTDTL 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	164/518 (32%)
Ces5a	NP_001012056.2	Esterase_lipase	40..529	CDD:238191	169/555 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336105
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840