Protein Alignment Jhe and Ces1e

DIOPT Version :9

• Sequence 1: NP_001163166.1
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_113753.2
• Gene: Ces1e / 29225
• RGDID: 621508
• Length: 561
• Species: Rattus norvegicus
• Alignment Length: 633
• Identity: 177/633 - (27%)
• Similarity: 273/633 - (43%)
• Gaps: 146/633 - (23%)

  Fly     7 LQLLLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKG--TNLQGYQSERFEAFMGIPYALPPIG 69
            |.|:.|....||..|  ::|..||.|.      |.:.|  .:|:|: ::....|:|:|:|.||:|
  Rat     6 LILVFLAAFTAGGHP--SSLPVVDTLQ------GKVLGKYVSLEGF-TQPVAVFLGVPFAKPPLG 61

  Fly    70 DLRFSNPK-VMPKLLGMYDASAPKMDCIQKNYLLPTPV---VYGD--------------EDCLYL 116
            .|||:.|: ..|........|.|.| |.|      .||   :..|              ||||||
  Rat    62 SLRFAPPQPAEPWSFVKNTTSYPPM-CSQ------DPVAGQIVNDLLTNREENISLQFSEDCLYL 119

  Fly   117 NVYRPE--IRKSALPVMVYIHGGGFFGGSA----GPGVTGPEYFMDSGEVILVTMAYRLGPFGFL 175
            |:|.|.  .::..|||||:|||||...|.|    |..::..|      .|::|.:.||||.:||.
  Rat   120 NIYTPADLTKRDRLPVMVWIHGGGLVLGGASTYDGLALSTHE------NVVVVVIQYRLGIWGFF 178

  Fly   176 STQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRV 240
            ||.|....||:|..||..||.|||.||..|||||..|||||:||||.:..:.:|||.:..|||:.
  Rat   179 STGDEHSRGNWGHLDQVAALHWVQDNIDNFGGDPGSVTIFGESAGGESVSVLVLSPLAKNLFHKA 243

  Fly   241 ISMSGTANVPFAIAEQPLEQARLLAE-FADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWD 304
            ||.||.|    ..|....:..|.||| .|.|...::.::..:...||:....:||.....|..:.
  Rat   244 ISESGVA----LTAGLVKKNTRPLAEKIAVVSGCKSTTSAAMVHCLRQKTEEELLETTLKLNLFS 304

  Fly   305 VD-HMTN-----FRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNE 363
            :| |..:     |.|.|.:|:    .|...|.::||:....::|.::|          :|
  Rat   305 LDLHGDSRQSYPFVPTVLDGV----VLPKMPEEILAEKDFNTVPYIVG----------IN----- 350

  Fly   364 TLRQSF-------------NLRFDELLQELLEFPASFSQDRREKMMDLLVEVYF-------QGQH 408
              :|.|             :::.|.:....|...:||..:..|:.:.:.||.|.       :.:.
  Rat   351 --KQEFGWILPTMMNYPPSDMKLDPMTATSLLKKSSFLLNLPEEAIPVAVEKYLRHTDDPDRNKD 413

  Fly   409 EVNEL---TVQGFMNLISDRGFKQPLYNTIHKNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTG 470
            ::.||   .:.|..::|..||.:.....|            |:|.|.|:.  |::|....:.|.|
  Rat   414 QLLELIGDVIFGVPSVIVSRGHRDAGART------------YMYEFQYRP--SFSSKMKPSTVVG 464

  Fly   471 KYGVVHCDDLLYLFRSPLLFPDFQRNSTEAKVIH---SFVDYFVHFAKFGKPRNSESLTPCSIEV 532
            .:|    |::..:|.:|:|     |..|..:.|:   ..:.::.:||:.|.|..
  Rat   465 DHG----DEIYSVFGAPIL-----RGGTSKEEINLSKMMMKFWANFARNGNPNG----------- 509

  Fly   533 LQSRPDGICDYHEFANAPDAYQ-GFEVHVASEFQTDRVNLWSHILNEK 579
                 .|:..:.|:.......| |.....|.:.:...|..||.:|..|
  Rat   510 -----QGLPHWPEYDQKEGYLQIGATTQQAQKLKEKEVAFWSELLAMK 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	157/545 (29%)
Ces1e	NP_113753.2	COesterase	24..545	CDD:278561	166/604 (27%)
		Aes	43..>239	CDD:223730	83/209 (40%)
		Prevents secretion from ER (Potential)	558..561

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010