DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhe and Ces4a

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001099646.1	Gene:	Ces4a / 291955	RGDID:	1307418	Length:	563	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	167/546 - (30%)
Similarity:	252/546 - (46%)	Gaps:	70/546 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LQLLLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKGTNLQGYQ----SERFEAFMGIPYALPP 67
            |.|.|:.|...|      ||.|.:.|.:....:       |||.|    ......|:|:|::.||
  Rat    16 LTLWLVVQTALG------ALHTKEPLLITKHGI-------LQGKQVHVGDTPIRVFLGVPFSQPP 67

  Fly    68 IGDLRFSNPKVMPKLLGMYDASAPKMDCIQKNYLLPTPV----------VYGDEDCLYLNVYRPE 122
            :|..||:.|:......|:.||:.....|:|:::...|.:          ::..|||||||||.|.
  Rat    68 VGTRRFAPPEPPLPWNGIRDATTYPPSCLQESWGQITSMYLNTRKQYEWLHFSEDCLYLNVYAPV 132

  Fly   123 IRKS--ALPVMVYIHGGGFFGGSAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGN 185
            :...  .|||||:..||.|..|||.. ..|.| ....|:|:||.:.||||..||.||.::...||
  Rat   133 LAPGDPLLPVMVWFPGGAFLVGSAST-YEGSE-LAARGKVVLVFLQYRLGILGFFSTGNSHARGN 195

  Fly   186 FGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVP 250
            :||.||..||||||.||..|||||..||:||||||.::....|:||.:.||||:.||.||||.:.
  Rat   196 WGLLDQIAALRWVQENIEAFGGDPDSVTLFGQSAGAMSVSGLLMSPLAQGLFHQAISQSGTAVLK 260

  Fly   251 FAIAEQPLEQARLLAEFADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYW------DVDHMT 309
            ..|...||:.|:.:|..|   ...:.||..:.|.|:.:.|.|::.....:.::      |...:.
  Rat   261 TFITHDPLKSAKKIAHLA---GCDHNSTKIMVKCLKALPAEKVMLVSKKMTFFRANSHKDPKDIV 322

  Fly   310 NFRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNETLRQSFNLRFD 374
            .|...|.:||    .....|:.:|.:|....:|.|||....|....:..::..:..::..|..:
  Rat   323 WFLSPVVDGL----VFPEDPVVLLTRGQVKPVPYLLGVNSAEFEWSLPFLMKLQLNQRIMNKNY- 382

  Fly   375 ELLQELLEFPASFSQDRREKMMDLLVEVYFQG--QHEVNELTVQGFMNLISDRGFKQPLYNTIHK 437
              :.:|| :..|...:..|:.:.|:...|...  .|...::.....::|:.|..|   :|.|:..
  Rat   383 --ITKLL-WSCSILLNITEEQIPLVAREYLSDAISHHDWKMFRNHLIDLVGDATF---VYATLQA 441

  Fly   438 NVCH--TPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPLLFPDFQRNST-- 498
            ...|  ..:|||||.|.:..|.......:.       |..|.|:|.|||.||     |.:.|:
  Rat   442 ARYHRDAGSPVYLYEFKHHAPGIIVKPRSD-------GADHGDELSYLFGSP-----FSKGSSRG 494

  Fly   499 -EAKVIHSFVDYFVHFAKFGKPRNSE 523
             |.:.....:.|:.:||..|.|.:.|
  Rat   495 EEKEFSLQMMKYWANFAHTGDPNDRE 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	158/513 (31%)
Ces4a	NP_001099646.1	COesterase	33..554	CDD:395084	159/523 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336401
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850