DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhe and Ces2g

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001099645.1	Gene:	Ces2g / 291952	RGDID:	1308358	Length:	560	Species:	Rattus norvegicus

Alignment Length:	495	Identity:	159/495 - (32%)
Similarity:	229/495 - (46%)	Gaps:	75/495 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 FMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDCIQ---------KNYLLPTPVVYGDEDC 113
            |:|||:|..|:|.|||:.|:......|:.|.::....|.|         |...|..|.|...|||
  Rat    60 FLGIPFAKAPVGPLRFAPPEAPEPWSGVRDGTSQSNICPQNVRMNMEGLKEMKLTLPPVSMSEDC 124

  Fly   114 LYLNVYRP--EIRKSALPVMVYIHGGGFFGGSA----GPGVTGPEYFMDSGEVILVTMAYRLGPF 172
            ||||:|.|  ....|.|||||:||||....|.|    |..:...|      :|::||:.||||..
  Rat   125 LYLNIYAPAHAHEGSHLPVMVWIHGGALTVGMASMYDGSMLAATE------DVVVVTIQYRLGVL 183

  Fly   173 GFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLF 237
            ||.||.|....||:|..||..||||||:||..|||:|..|||||:||||::...|::||.|.|||
  Rat   184 GFFSTGDHHARGNWGYLDQVAALRWVQQNIAHFGGNPDCVTIFGESAGGLSVSSHVVSPMSKGLF 248

  Fly   238 HRVISMSGTANVP---FAIAEQPLEQARLLAEFADVPDARNLSTVKLTKALRRINATKLLNAGDG 299
            ||.|..||.|.:|   |..:|...:....|:. .:..|..:|......|:..:|..
  Rat   249 HRAIMESGVALMPGTIFNFSEMVYQMVVKLSG-CEAMDPESLVHCLRGKSEEQITV--------- 303

  Fly   300 LKYWDVDHMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGN-E 363
                 :.......|.|.:|    .||..||.::||......:|.::|....|....|..::|: :
  Rat   304 -----ISKEFQMIPAVVDG----EFLPNHPQELLASADFHPVPSIIGFNNDEYGWIVPKVIGSAQ 359

  Fly   364 TLRQSFNLRFDELLQELLEFPASFSQDRREKMM------DLLVEVYFQGQHEVNELTVQGFMNLI 422
            |::        .:.:|.|:   :|.:|...:||      |||:|.|.....:...|..| |..::
  Rat   360 TIK--------GITRENLQ---AFLKDTAPQMMLPPECSDLLMEEYMGDIEDPQTLQAQ-FTEMM 412

  Fly   423 SDRGFKQPLYNTIHKNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSP 487
            .|..|..|..........|.  |||.|.|.:|.  |:.......:|...:|    |::.::|.|
  Rat   413 EDFMFVIPSLQVARFQRSHA--PVYFYEFQHQS--SFLKDIRPPHVKADHG----DEVPFVFGS- 468

  Fly   488 LLFPDFQRNSTEAKVI--HSFVDYFVHFAKFGKPRNSESL 525
             .|...:.|.||.:.:  ...:.|:.:||::|.| ||.||
  Rat   469 -FFWGMKLNLTEGEKLLNRRMMKYWANFARYGNP-NSNSL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	159/495 (32%)
Ces2g	NP_001099645.1	COesterase	31..539	CDD:278561	159/495 (32%)
Ces2g	NP_001099645.1	Aes	<129..>232	CDD:223730	52/108 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336194
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840