Protein Alignment Jhe and CES4A

DIOPT Version :9

• Sequence 1: NP_001163166.1
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 617
• Identity: 183/617 - (29%)
• Similarity: 263/617 - (42%)
• Gaps: 161/617 - (26%)

  Fly     7 LQLLLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKGTNLQGYQ----SERFEAFMGIPYALPP 67
            |.|.|:.|...|      ||.|.      .|.|....|| |||.|    ....:.|:|:|::.||
Human    32 LTLCLMAQTALG------ALHTK------RPQVVTKYGT-LQGKQMHVGKTPIQVFLGVPFSRPP 83

  Fly    68 IGDLRFSNPKVMPKLLGMYDAS----------APKMDCIQKN------------YLLPTPV-VYG 109
            :|.|||:.|:......|:.||:          :|....:.::            .|||.|: ::|
Human    84 LGILRFAPPEPPEPWKGIRDATTYPPGWSLALSPGWSAVARSRLTATSASRVQASLLPQPLSIWG 148

  Fly   110 ---------------------------DEDCLYLNVYRPEIRKS--ALPVMVYIHGGGFFGGSA- 144
                                       .|||||||||.|.....  .|||||:..||.|..|:|
Human   149 YRCLQESWGQLASMYVSTRERYKWLRFSEDCLYLNVYAPARAPGDPQLPVMVWFPGGAFIVGAAS 213

  Fly   145 ---GPGVTGPEYFMDSGEVILVTMAYRLGPFGFL----STQDAVMSGNFGLKDQNLALRWVQRNI 202
               |..:...|      :|:||.:.:|||.||||    .|.|:...||:||.||..||||||.||
Human   214 SYEGSDLAARE------KVVLVFLQHRLGIFGFLRWRGRTDDSHARGNWGLLDQMAALRWVQENI 272

  Fly   203 RFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLAEF 267
            ..|||||..||:||||||.::....::||.:.|||||.||.||||.....|...||:.|:.:|..
Human   273 AAFGGDPGNVTLFGQSAGAMSISGLMMSPLASGLFHRAISQSGTALFRLFITSNPLKVAKKVAHL 337

  Fly   268 ADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVDHMTNFR-----------PVVEEGLEV 321
            |   ...:.||..|...||.::.||::...:.:::..:    ||:           |||:..:..
Human   338 A---GCNHNSTQILVNCLRALSGTKVMRVSNKMRFLQL----NFQRDPEEIIWSMSPVVDGVVIP 395

  Fly   322 DAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNETLRQSFNLRFDELLQELLEFPAS 386
            |     .|:.:|.||..:|:|.|||          ||           ||.|:.||..:::||.:
Human   396 D-----DPLVLLTQGKVSSVPYLLG----------VN-----------NLEFNWLLPYIMKFPLN 434

  Fly   387 FSQDRRE---KMM--------------DLLVEVYFQGQHEVN-ELTVQGFMNLISDRGFKQPLYN 433
            ....|:|   ||:              .|:||.|....:|.: ::.....|:::.|..|   :|.
Human   435 RQAMRKETITKMLWSTRTLLNITKEQVPLVVEEYLDNVNEHDWKMLRNRMMDIVQDATF---VYA 496

  Fly   434 TIHKNVCHTPN--PVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPLLFPDFQRN 496
            |:.....|...  |||||.|.:..........|.       |..|.|::.:||..|  |......
Human   497 TLQTAHYHRDAGLPVYLYEFEHHARGIIVKPRTD-------GADHGDEMYFLFGGP--FATGLSM 552

  Fly   497 STEAKVIHSFVDYFVHFAKFGKPRNSESLTPC 528
            ..|..:....:.|:.:||:.|.|.:..  .||
Human   553 GKEKALSLQMMKYWANFARTGNPNDGN--LPC 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	171/581 (29%)
CES4A	XP_011521323.1	COesterase	46..613	CDD:278561	176/597 (29%)
		Aes	<184..>291	CDD:223730	53/112 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142732
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850