DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhe and Tg

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_112250.2	Gene:	Tg / 24826	RGDID:	3848	Length:	2768	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	155/547 - (28%)
Similarity:	222/547 - (40%)	Gaps:	97/547 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VCPPSV-----GCLKGTN---------LQGYQSERFEAFMGIPYALPPIGDLRFSNPKVMPKLLG 84
            :..|||     |.|:|.:         .|.||      |:|:|||.||:.:.||..|:|: ...|
  Rat  2197 ISTPSVHIDSFGQLQGGSQVVKVGTAWKQVYQ------FLGVPYAAPPLAENRFQAPEVL-NWTG 2254

  Fly    85 MYDASAPKMDCIQKNYLLPTPVVYGDEDCLYLNVYRPEIRKSALPVMVYIHGGGFFGGSAGPGVT 149
            .:||:..:..|.|.....|||... .||||||||:.||...|...|:|:.|......||.|....
  Rat  2255 SWDATKLRSSCWQPGTRTPTPPQI-SEDCLYLNVFVPENLVSNASVLVFFHNTVEMEGSGGQLNI 2318

  Fly   150 GPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTI 214
            ........|.:|:||..||||.|||||:....::||:||.||..||.|||.:|..|||||||||:
  Rat  2319 DGSILAAVGNLIVVTANYRLGVFGFLSSGSDEVAGNWGLLDQVAALTWVQTHIGAFGGDPQRVTL 2383

  Fly   215 FGQSAGGVAAHMHLL--SPRSHGLFHRVISMSGTANVPFAI--AEQPLEQARLLAEFADVPDARN 275
            .....|...|.:|||  .|....||.:.:.|.|:|..|.||  .::..:||..||:....|   |
  Rat  2384 AADRGGADVASIHLLITRPTRLQLFRKALLMGGSALSPAAIISPDRAQQQAAALAKEVGCP---N 2445

  Fly   276 LSTVKLTKALRRINA-------TKLLNAGDGLKYWDVDHMTNFRPVVEEGLEVDAFLNAHPMDML 333
            .|..::....|:..|       ||||.......||.        |||:     ..:|...|...|
  Rat  2446 SSVQEVVSCFRQKPANILNEAQTKLLAVSGPFHYWG--------PVVD-----GQYLRELPSRRL 2497

  Fly   334 AQGMPTSIPLLLGTVPGEGAV---RVVNILGNETLRQSFNLRFDELLQELLEFPASFSQDRREKM 395
            .:.:|..:.||:|....:|.:   :.|........|.:....|.:.||..|.     .:|...::
  Rat  2498 KRPLPVKVDLLIGGSQDDGLINRAKAVKQFEESQGRTNSKTAFYQALQNSLG-----GEDSDARI 2557

  Fly   396 MDLLVEVYFQGQHEVNELTVQGFMNLISDRGFKQPLYNTIHKN--VCHTPNPVYLYS-------F 451
            :...: .|:..:|..::..           .|.:.|.|.....  :|...|...|::       |
  Rat  2558 LAAAI-WYYSLEHSTDDYA-----------SFSRALENATRDYFIICPIVNMASLWARRTRGNVF 2610

  Fly   452 NYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPLL-----FPDFQRNSTEAKVIHSFVDYFV 511
            .|..|.||          |...:....|:.|.|..|..     :...:..|...||    :.||.
  Rat  2611 MYHVPESY----------GHGSLELLADVQYAFGLPFYSAYQGYFSMEEQSLSLKV----MQYFS 2661

  Fly   512 HFAKFGKPRNSESLTPCSIEVLQSRPD 538
            :|.:.|.|......:..:.|.....||
  Rat  2662 NFIRSGNPNYPHEFSQKAAEFATPWPD 2688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	149/523 (28%)
Tg	NP_112250.2	TY	34..93	CDD:238114
		TY	96..161	CDD:238114
		TY	164..249	CDD:294100
		TY	301..359	CDD:238114
		TY	<613..658	CDD:238114
		TY	661..724	CDD:238114
		TY	730..>776	CDD:294100
		TY	<893..922	CDD:238114
		TY	1005..1074	CDD:238114
		TY	1150..1211	CDD:238114
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1455..1468
		GCC2_GCC3	1464..1509	CDD:285001
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1469..1485
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1486..1502
		TY	1519..1566	CDD:214561
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1602..1722
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1723..1891
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1892..1994
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1995..2127
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	2128..2185
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768		155/547 (28%)
		COesterase	2198..2719	CDD:278561	155/546 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2731..2768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336409
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930