DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhe and Cel

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_058693.2	Gene:	Cel / 24254	RGDID:	2331	Length:	612	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	170/545 - (31%)
Similarity:	248/545 - (45%)	Gaps:	67/545 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LQLLLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKGTN--LQGYQSERFEAFMGIPYALPPIG 69
            |::|.||...      |.|.|...:|.......|.::|.|  |.....:..:.|.|||:|...
  Rat     4 LEVLFLGLTC------CLAAACAAKLGAVYTEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAK-- 60

  Fly    70 DLRFSNPKVMPKLLGMYDASAPKMDCIQKNYLLPTPVVYGDEDCLYLNVYRPEIRKSA---LPVM 131
              ...||:..|...|...|:..|..|:|..  :.....||.|||||||::.|:.||..   ||||
  Rat    61 --TLENPQRHPGWQGTLKATDFKKRCLQAT--ITQDDTYGQEDCLYLNIWVPQGRKQVSHDLPVM 121

  Fly   132 VYIHGGGFFGGSAGPGVTGPEYFMDSGE-------VILVTMAYRLGPFGFLSTQDAVMSGNFGLK 189
            |:|:||.|..|| |.|....:.::..||       ||:||..||:||.|||||.||.:.|||||:
  Rat   122 VWIYGGAFLMGS-GQGANFLKNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNFGLR 185

  Fly   190 DQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIA 254
            ||::|:.||:|||..|||||..:||||:|||..:..:..|||.:.||..|.||.||.|..|:||.
  Rat   186 DQHMAIAWVKRNIAAFGGDPDNITIFGESAGAASVSLQTLSPYNKGLIRRAISQSGVALSPWAIQ 250

  Fly   255 EQPLEQARLLAEFADVPDARNLSTVKLTKALRRINATKLLNAGDGL----KYWDVDHMTNFRPVV 315
            |.||..|:.:|:....|..   .|.|:...| :|...:.|.....|    :.:.:.|...|.|||
  Rat   251 ENPLFWAKTIAKKVGCPTE---DTAKMAGCL-KITDPRALTLAYRLPLKSQEYPIVHYLAFIPVV 311

  Fly   316 EEGL----EVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNETLRQSFN--LRFD 374
            :...    .::.:.||..:|.|| |:......|..||.    |..::....:...:.|.  :...
  Rat   312 DGDFIPDDPINLYDNAADIDYLA-GINDMDGHLFATVD----VPAIDKAKQDVTEEDFYRLVSGH 371

  Fly   375 ELLQELLEFPASFSQDRREKMMDLLVEVYFQGQHEVN-ELTVQGFMNLISDRGFKQPLYNTIHKN 438
            .:.:.|....|:|         |:..|.:.|...:.| :.||..|.   :|..|..|....:.::
  Rat   372 TVAKGLKGTQATF---------DIYTESWAQDPSQENMKKTVVAFE---TDILFLIPTEMALAQH 424

  Fly   439 VCHTPN-PVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPLLFPDFQRNSTEAKV 502
            ..|..: ..|.|.|::...:.....:..|:        |.|||.|:|..|...|...| :.:..|
  Rat   425 RAHAKSAKTYSYLFSHPSRMPIYPKWMGAD--------HADDLQYVFGKPFATPLGYR-AQDRTV 480

  Fly   503 IHSFVDYFVHFAKFGKPRNSESLTP 527
            ..:.:.|:.:|||.|.|....|..|
  Rat   481 SKAMIAYWTNFAKSGDPNMGNSPVP 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	161/510 (32%)
Cel	NP_058693.2	COesterase	26..542	CDD:278561	162/517 (31%)
		Aes	<118..>247	CDD:223730	66/129 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..612
		4 X 11 AA tandem repeats, O-glycosylated region	556..599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336382
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740