DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhe and Ces2b

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_937814.1	Gene:	Ces2b / 234669	MGIID:	2448547	Length:	556	Species:	Mus musculus

Alignment Length:	602	Identity:	171/602 - (28%)
Similarity:	264/602 - (43%)	Gaps:	108/602 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKGTNLQGYQSER-FEAFMGIPYALPPIGDLR 72
            |||||.:.....|..:.:...        ..|.::|:.:....::. ...|:|||:|.||:|.||
Mouse    18 LLLLGHVQGQDSPEASPIRNT--------HTGQVRGSLVHVKDTKAGVHTFLGIPFAKPPVGPLR 74

  Fly    73 FSNPKVMPKLLGMYDASAPKMDCIQ-----KNYLLPTPVVYGDEDCLYLNVYRP--EIRKSALPV 130
            |:.|:......|:.|.:|....|:|     |...|..|.|...|||||||:|.|  ....|.|||
Mouse    75 FAPPEAPEPWSGVRDGTAHPAMCLQNLGVMKEIKLKLPPVSTSEDCLYLNIYTPAHAHEGSNLPV 139

  Fly   131 MVYIHGGGFFGGSAGPGVTGPEYFMDSG-------EVILVTMAYRLGPFGFLSTQDAVMSGNFGL 188
            ||:|||||...|.|.         |..|       ::::||:.||||..||.||.|....||:|.
Mouse   140 MVWIHGGGLVAGMAS---------MYDGSLLAAIEDLVVVTIQYRLGVLGFFSTGDQHARGNWGF 195

  Fly   189 KDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAI 253
            .||..||||:|:||..|||.|.||||||:||||.:...|::||.|.||||..|..||.|.:|:.|
Mouse   196 LDQVAALRWIQQNIAHFGGKPDRVTIFGESAGGTSVSSHVVSPMSKGLFHGAIMESGVALLPYLI 260

  Fly   254 AEQPLEQARLLAEFADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVDHMTNFRPVVEEG 318
            .:   ....:....|.:.....:.:..|.:.||..:..::|         .::.:....|.|.:|
Mouse   261 TD---TSEMVSTTVAKLSGCEAMDSEALVRCLRGKSEAEIL---------AINKLVQMIPAVVDG 313

  Fly   319 LEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGN-ETLRQSFNLRFDELLQELLE 382
                .|...||.::||......:|.::|....|....:..::|: :|::        |:.:|.|:
Mouse   314 ----EFFPRHPKELLASEDFHPVPSIIGVNNDEFGWTIPVVMGSAQTIK--------EITRENLQ 366

  Fly   383 FPASFSQDRREKMM-----DLLVEVYFQGQHEVNELTVQGFMNLISDRGFKQPLYNTIHKNVCHT 442
              |.......:.|:     |||:|.|.....:...|.:| |..::.|..|..|.....:....|.
Mouse   367 --AVLKNTTAQLMLPPECSDLLMEEYMGDTEDAQTLQIQ-FTEMMEDFMFVIPALQVAYFQRSHA 428

  Fly   443 PNPVYLYSFNYQGPLSYAS------AYTSANVTGKYGVVHCDDLLYLFRSPLLFPDFQRNSTEAK 501
              .||.|.|.:|    .||      .:..|:        |.|::.::|  ...|.|.:.:.||.:
Mouse   429 --SVYFYEFQHQ----IASLKDVRPTHVKAD--------HADEIPFVF--GYFFWDMKLDFTEGE 477

  Fly   502 VIHS--FVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICDYHEFANAPDAYQGFEVH--VAS 562
            .:.|  .:.|:.:||:.|.| |||.|                .|....:..:.|...:..  |..
Mouse   478 KLLSRRMMKYWANFARHGNP-NSEGL----------------PYWPVMDHDEQYLQLDTQPAVGR 525

  Fly   563 EFQTDRVNLWSHILNEK 579
            ..::.|:..|:..|::|
Mouse   526 ALKSRRLQFWTKTLSQK 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	158/515 (31%)
Ces2b	NP_937814.1	COesterase	34..535	CDD:365897	162/577 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832661
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840