Protein Alignment Jhe and Aadacl3

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_001078972.1
• Gene: Aadacl3 / 230883
• MGIID: 2685281
• Length: 408
• Species: Mus musculus
• Alignment Length: 293
• Identity: 59/293 - (20%)
• Similarity: 106/293 - (36%)
• Gaps: 91/293 - (31%)

  Fly   116 LNVYRPEIRKSALPVM--VYIHGGGFFGGSAGPGVTGPEYFMDSGEVILVTMAYRLGP-FGF-LS 176
            :.:|:|: :.|::|.:  ::.||||...||.....:.........:.::|::.||..| :.: :.
Mouse   100 VKLYKPK-KPSSIPRLGIIFFHGGGTIIGSLRTHNSICLRLSKECDSVVVSVGYRKSPMYKYPVM 163

  Fly   177 TQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVI 241
            ..|.|::....|:           ::..:|.||.||...|.|.||.||     :..|..|.||
Mouse   164 KDDCVVATTHFLE-----------SLDVYGVDPARVVTCGDSVGGTAA-----TVTSQMLVHR-- 210

  Fly   242 SMSGTANVPFAIAEQPLEQARLLAEFADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWD-- 304
              .....:...|...||.|   |.:|......:|.:...|:                    ||
Mouse   211 --PDLPRIKAQILIYPLLQ---LIDFGSPSYQQNRNIPLLS--------------------WDLA 250

  Fly   305 -------VDHMTNFRPVVEEGLEVDAFLNAHPMDML--------AQGMP--------TSIPLLLG 346
                   :|...:::.||:.|:.:       |.|:.        |:.:|        .|||  .|
Mouse   251 FYCFCCHLDVNISWKSVVKNGMHL-------PPDVWEKYRKWLGAENIPERFKNRGYKSIP--WG 306

  Fly   347 TVPGEGAVRVVNILGNETLRQSFNLRFDELLQE 379
            .|..:         ..:.:::|.|.....|:.|
Mouse   307 PVNND---------AYQEIKRSLNYTCSPLISE 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	59/293 (20%)
Aadacl3	NP_001078972.1	Abhydrolase_3	116..379	CDD:400284	55/276 (20%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	120..122		1/1 (100%)