Protein Alignment Jhe and NLGN1

DIOPT Version :9

• Sequence 1: NP_001163166.1
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Alignment Length: 674
• Identity: 184/674 - (27%)
• Similarity: 279/674 - (41%)
• Gaps: 166/674 - (24%)

  Fly     7 LQLLLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKGTN---LQGYQSERFE-------AFMGI 61
            |.|.:||.||.........|..||.|.          .||   ::|.:.|...       .|:|:
Human    29 LTLCMLGCLLQAGHVLSQKLDDVDPLV----------ATNFGKIRGIKKELNNEILGPVIQFLGV 83

  Fly    62 PYALPPIGDLRFSNPK----------------VMPKLLGMYDASAPKMDCIQKNYLLPT------ 104
            |||.||.|:.||..|:                |.|:  .:.|...|::       :||.
Human    84 PYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQ--NIIDGRLPEV-------MLPVWFTNNL 139

  Fly   105 PVVYG-----DEDCLYLNVYRP-----------------------EIRKSA--LPVMVYIHGGGF 139
            .||..     .|||||||:|.|                       :||.|.  .|||||||||.:
Human   140 DVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSY 204

  Fly   140 FGGSAGPGVTGPEY----FMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQR 200
            ..|      ||..|    ....|.||::|:.||||..|||||.|....||:||.|...||||...
Human   205 MEG------TGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSE 263

  Fly   201 NIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSH---------GLFHRVISMSGTANVPFAIAEQ 256
            ||.||||||.|:|:||..|||...::..||..|.         |||.|.|:.||||...:|::.|
Human   264 NIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQ 328

  Fly   257 PLEQARLLAE--FADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVD----HMTNFRPVV 315
            |.:.||:||.  ..:|.|     ||:|.:.|::....:|::.       |:.    |:. |.||:
Human   329 PAKYARMLATKVGCNVSD-----TVELVECLQKKPYKELVDQ-------DIQPARYHIA-FGPVI 380

  Fly   316 EEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNE--TLRQSFNLRFDELLQ 378
            :..:..|     .|..::.||...:..::||...|||...|.||:.::  .....|:......:.
Human   381 DGDVIPD-----DPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVD 440

  Fly   379 ELLEFPASFSQDRREKMMDLLVEVYFQGQHEVN-ELTVQGFMNLISDRGFKQPLYNT--IHKNVC 440
            .|..:|     :.::.:.:.:..:|.......| |...:..:.|.:|..:..|...|  :|.|.
Human   441 NLYGYP-----EGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNF- 499

  Fly   441 HTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPL-----LFP-DFQRNSTE 499
              .:|.|.|:|.:........|:..|        .|.|::.|:...|:     ||| :|.:|...
Human   500 --GSPTYFYAFYHHCQTDQVPAWADA--------AHGDEVPYVLGIPMIGPTELFPCNFSKNDVM 554

  Fly   500 AKVIHSFVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICD--YHEFANAPDAYQ--GFEVHV 560
            ...:  .:.|:.:|||.|.|...   .|...:.:.::|:...:  :..::.....|.  |.:..|
Human   555 LSAV--VMTYWTNFAKTGDPNQP---VPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRV 614

  Fly   561 ASEFQTDRVNLW------SHILNE 578
            ...::.::||||      .|.||:
Human   615 KEHYRANKVNLWLELVPHLHNLND 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	162/578 (28%)
NLGN1	NP_001352852.1	COesterase	53..626	CDD:365897	170/636 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142636
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740