Protein Alignment Jhe and CES5A

DIOPT Version :9

• Sequence 1: NP_001163166.1
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_001177087.1
• Gene: CES5A / 221223
• HGNCID: 26459
• Length: 604
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 166/585 - (28%)
• Similarity: 264/585 - (45%)
• Gaps: 117/585 - (20%)

  Fly    36 PPSVGCLKGTNLQGYQSER---------FEAFMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAP 91
            |.:.|..:.|.|...|.::         ...|:|:|:|.||:|.|||:||:.......:.:|::.
Human    55 PSAEGPQRNTRLGWIQGKQVTVLGSPVPVNVFLGVPFAAPPLGSLRFTNPQPASPWDNLREATSY 119

  Fly    92 KMDCIQKN-------YLLPT--PVVYGDEDCLYLNVYRPEIRK--SALPVMVYIHGGGFFGGSA- 144
            ...|:|.:       ::|..  |.....|||||||:|.|....  |.|||:|:..||.|..|||
Human   120 PNLCLQNSEWLLLDQHMLKVHYPKFGVSEDCLYLNIYAPAHADTGSKLPVLVWFPGGAFKTGSAS 184

  Fly   145 ---GPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFG 206
               |..:...|      :|::|.:.||||.|||.:|.|....||:..|||..||.|||:||.|||
Human   185 IFDGSALAAYE------DVLVVVVQYRLGIFGFFTTWDQHAPGNWAFKDQVAALSWVQKNIEFFG 243

  Fly   207 GDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAE--QPLEQARLLAEFAD 269
            |||..|||||:|||.::....:|||.:.||||:.|..||.|.:|:..|.  :..|..:::|.|.
Human   244 GDPSSVTIFGESAGAISVSSLILSPMAKGLFHKAIMESGVAIIPYLEAHDYEKSEDLQVVAHFC- 307

  Fly   270 VPDARNLS-TVKLTKALRRINATKLLNAGDGLKYWDVDHMTNFRPVVEEGLEVDAFLNAHPMDML 333
               ..|.| :..|.:.||...:.:||......|        :|..||:     .||....|:|:|
Human   308 ---GNNASDSEALLRCLRTKPSKELLTLSQKTK--------SFTRVVD-----GAFFPNEPLDLL 356

  Fly   334 AQGMPTSIPLLLGT--------VPGEGAVRVVNILGNETLRQSFNLRFDELLQELLEFPASFSQD 390
            :|....:||.::|.        :|.:.|..::: ..|::|..       .|:|.:|..|..:
Human   357 SQKAFKAIPSIIGVNNHECGFLLPMKEAPEILS-GSNKSLAL-------HLIQNILHIPPQY--- 410

  Fly   391 RREKMMDLLVEVYFQGQHEVNELTVQGFMNLISDRGFKQPLYNT--IHKNVCHTPNPVYLYSFNY 453
                 :.|:...||..:|.:.|:. ...::|:.|..|..|...|  .|::   ...|||.|.|.:
Human   411 -----LHLVANEYFHDKHSLTEIR-DSLLDLLGDVFFVVPALITARYHRD---AGAPVYFYEFRH 466

  Fly   454 QGPLSYAS---AYTSANVTGKYGVVHCDDLLYLFRSPLLFPD---FQRNSTEAKVI-HSFVDYFV 511
            : |..:..   |:..|:        |.|::.::|....|..|   |:..:.|.|:: ...:.|:.
Human   467 R-PQCFEDTKPAFVKAD--------HADEVRFVFGGAFLKGDIVMFEGATEEEKLLSRKMMKYWA 522

  Fly   512 HFAKFGKPR-NSESLTPCSIEVLQSRPDGICDYHEFANAPDAYQGFEVHVA--SEFQTDRVNLWS 573
            .||:.|.|. |..||.|.                  .|..:.|...:::::  ...:..||:.|:
Human   523 TFARTGNPNGNDLSLWPA------------------YNLTEQYLQLDLNMSLGQRLKEPRVDFWT 569

  Fly   574  573
            Human   570  569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	159/531 (30%)
CES5A	NP_001177087.1	COesterase	56..568	CDD:278561	164/581 (28%)
		Aes	<155..>258	CDD:223730	51/108 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142593
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840