DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhe and Ces2e

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001093947.1	Gene:	Ces2e / 192257	RGDID:	621563	Length:	557	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	166/553 - (30%)
Similarity:	250/553 - (45%)	Gaps:	98/553 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 FMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDCIQ----------KNYLLPTPVVYGDED 112
            |:|||:|.||||.|||:.|:......|:.|.::....|:|          |..:..:||.. .||
  Rat    58 FLGIPFAKPPIGPLRFAPPEPPEPWSGVRDGTSHPAMCLQNIDGLNLENLKIKMSRSPVSM-SED 121

  Fly   113 CLYLNVYRP--EIRKSALPVMVYIHGGGFFGGSA----GPGVTGPEYFMDSGEVILVTMAYRLGP 171
            ||||::|.|  ..:.|.|||||:|||||...|.|    |..:...|      :|::||:.||||.
  Rat   122 CLYLSIYTPAHTHKDSNLPVMVWIHGGGLCWGMASTYDGSMLAAIE------DVVVVTIQYRLGI 180

  Fly   172 FGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGL 236
            .||.||.|....||:|..||..||||||:||..|||:|.||||||:||||::...|::||.|.||
  Rat   181 LGFFSTGDEHARGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVSPMSQGL 245

  Fly   237 FHRVISMSGTANVPFAIAEQPLEQARLLAEFADVPDARNLSTVKLTKALRRINATKLLNAGDGLK 301
            ||..|..||.|.:|..|:.   ....:....|::.....:.:..|...||..:..::|
  Rat   246 FHGAIMESGVALLPNLISN---TSEVIYTMVANLSGCEPVDSEALMSCLREKSEEEML------- 300

  Fly   302 YWDVDHMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLG--------TVP---GEGAVR 355
              .::::......|.:|    .||..||:::||......:|.::|        .:|   .:..::
  Rat   301 --AINNIVRTISGVVDG----KFLPRHPLELLASVDFHPVPSIIGINSDEYGWIIPMLHPDSTMK 359

  Fly   356 VVNILGNETLRQSFNLRFDELLQELLEFPASFSQDRREKMMDLLVEVYFQGQHEVNELTVQGFMN 420
            .:|   .||:|....   :..:|.:|  |...|        |||:|.|.....:...|.:| |..
  Rat   360 EIN---RETMRAVLK---NTAVQMML--PPECS--------DLLMEEYMGDTEDSKTLQIQ-FNE 407

  Fly   421 LISDRGFKQPLYNTIHKNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFR 485
            ::.|..|..|.....|....|.  |||.|.|.:|.  ::.......:|...:|    |:|.|:.
  Rat   408 MMGDFIFVIPALQVAHFQRSHA--PVYFYEFQHQS--NFLKDIRPPHVKADHG----DELPYVI- 463

  Fly   486 SPLLFPDFQRNSTEAKVIHS--FVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICDYHEFAN 548
             ..||.|.:...||.:.:.|  .:.|:.:||:.|.| |||.|                .|....:
  Rat   464 -GYLFWDMKFVFTEEEKLLSRKMIKYWANFARHGNP-NSEGL----------------PYWPALD 510

  Fly   549 APDAYQGFEVH--VASEFQTDRVNLWSHILNEK 579
            ..:.|...::.  |....:..|:..|:..|.:|
  Rat   511 HDEQYLQLDIQPVVGRALKARRLKFWTKTLPQK 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	159/497 (32%)
Ces2e	NP_001093947.1	COesterase	30..536	CDD:278561	163/544 (30%)
Ces2e	NP_001093947.1	Aes	<127..>230	CDD:223730	54/108 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336196
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840