Protein Alignment Jhe and Nlgn1

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: XP_006535478.1
• Gene: Nlgn1 / 192167
• MGIID: 2179435
• Length: 863
• Species: Mus musculus
• Alignment Length: 693
• Identity: 186/693 - (26%)
• Similarity: 279/693 - (40%)
• Gaps: 184/693 - (26%)

  Fly     7 LQLLLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKGTN---LQGYQSERFE-------AFMGI 61
            |.|.|||.||.........|..||.|..          ||   ::|.:.|...       .|:|:
Mouse    29 LTLCLLGCLLQTFHVLSQKLDDVDPLVT----------TNFGKIRGIKKELNNEILGPVIQFLGV 83

  Fly    62 PYALPPIGDLRFSNPK----------------VMPKLLGMYDASAPKMDCIQKNYLLPT------ 104
            |||.||.|:.||..|:                |.|:  .:.|...|::       :||.
Mouse    84 PYAAPPTGEHRFQPPEPPSPWSDIRNATQFAPVCPQ--NIIDGRLPEV-------MLPVWFTNNL 139

  Fly   105 PVVYG-----DEDCLYLNVYRP------------------------------------------- 121
            .||..     .|||||||:|.|
Mouse   140 DVVSSYVQDQSEDCLYLNIYVPTEDVKRISKECARKPGKKICRKGGPLTKKHTDDLGDNDGAEDE 204

  Fly   122 EIRKSA--LPVMVYIHGGGFFGGSAGPGVTGPEY----FMDSGEVILVTMAYRLGPFGFLSTQDA 180
            :||.|.  .|||||||||.:..|      ||..|    ....|.||::|:.||||..|||||.|.
Mouse   205 DIRDSGGPKPVMVYIHGGSYMEG------TGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQ 263

  Fly   181 VMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSH---------GL 236
            ...||:||.|...||||...||.||||||.|:|:||..|||...::..||..|.         ||
Mouse   264 AAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGL 328

  Fly   237 FHRVISMSGTANVPFAIAEQPLEQARLLAEFADVPDARNLS-TVKLTKALRRINATKLLNAGDGL 300
            |.|.|:.||||...:|::.||.:.||:||.....    |:| ||:|.:.|::....:|::.
Mouse   329 FQRAIAQSGTALSSWAVSFQPAKYARILATKVGC----NVSDTVELVECLQKKPYKELVDQ---- 385

  Fly   301 KYWDVD----HMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILG 361
               ||.    |:. |.||::..:..|     .|..::.||...:..::||...|||...|.||:.
Mouse   386 ---DVQPARYHIA-FGPVIDGDVIPD-----DPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVD 441

  Fly   362 NE--TLRQSFNLRFDELLQELLEFPASFSQDRREKMMDLLVEVYFQGQHEVN-ELTVQGFMNLIS 423
            ::  .....|:......:..|..:|     :.::.:.:.:..:|.......| |...:..:.|.:
Mouse   442 SDDGVSASDFDFAVSNFVDNLYGYP-----EGKDVLRETIKFMYTDWADRHNPETRRKTLLALFT 501

  Fly   424 DRGFKQPLYNT--IHKNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRS 486
            |..:..|...|  :|.|.   .:|.|.|:|.:........|:..|        .|.|::.|:...
Mouse   502 DHQWVAPAVATADLHSNF---GSPTYFYAFYHHCQTDQVPAWADA--------AHGDEVPYVLGI 555

  Fly   487 PL-----LFP-DFQRNSTEAKVIHSFVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICD--Y 543
            |:     ||| :|.:|......:  .:.|:.:|||.|.|...   .|...:.:.::|:...:  :
Mouse   556 PMIGPTELFPCNFSKNDVMLSAV--VMTYWTNFAKTGDPNQP---VPQDTKFIHTKPNRFEEVAW 615

  Fly   544 HEFANAPDAYQ--GFEVHVASEFQTDRVNLW------SHILNE 578
            ..::.....|.  |.:..|...::.::||||      .|.||:
Mouse   616 TRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLND 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	163/599 (27%)
Nlgn1	XP_006535478.1	COesterase	52..646	CDD:395084	172/656 (26%)