DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhe and cest-28

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_504691.2	Gene:	cest-28 / 187305	WormBaseID:	WBGene00019654	Length:	548	Species:	Caenorhabditis elegans

Alignment Length:	536	Identity:	148/536 - (27%)
Similarity:	223/536 - (41%)	Gaps:	111/536 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 CPPSVGCLKGTNLQGYQSERFEAFMGIPYALPPIGDLRFSNP-------------KVMPKLLGMY 86
            |.|..|     |:.....:..:.::|||:|.|.:   ||..|             |..|:.
Worm    21 CGPIQG-----NVYRIGDKTVDGYLGIPFAKPLV---RFKKPEPAGTWEEVRDCTKYGPRC---- 73

  Fly    87 DASAPKMDCI--QKNYLLPTPVVYGDE-DCLYLNVYRPEIRKS-----ALPVMVYIHGGGFFGGS 143
            ..|.|..:.|  ||:.:       .|| :||.|||: .:|..|     ..||||||||||:...:
Worm    74 PQSGPFAEAINFQKDDI-------PDEANCLTLNVF-SKISDSKNFNKTRPVMVYIHGGGYECSA 130

  Fly   144 AGP----GVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRF 204
            :..    .|.|.   :...:|::||:.||:|..||.:|.|.|..|||.|.|..|.|.|:|::|..
Worm   131 SRDYCDYSVAGT---LPLKDVVVVTLNYRVGILGFFTTGDTVCPGNFALWDLTLGLNWIQKHIES 192

  Fly   205 FGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLAEFA- 268
            |||||..:||||||||.....:..|||.|..||:|||.|||.|...:|: .....||::..|||
Worm   193 FGGDPGNITIFGQSAGAACVDLLALSPHSRDLFNRVIVMSGGALCEYAV-RTANSQAKVCYEFAR 256

  Fly   269 ----DVPDARNLSTVKLTKALRRINATKLLNA----GDGLKYWDVDHMTNFRPVVEEGLEVDAFL 325
                |..:::.|.....:|.|..|   :.:|.    ..|:..|..:...:|.|
Worm   257 HLGYDGTNSQTLFNWMKSKPLEEI---EKMNGFQVPASGILAWTPNLDDDFFP------------ 306

  Fly   326 NAHPMDMLAQGMPTSIPLLLGTVPGEG------------AVRVVNILGNETLRQSFNLRFDELLQ 378
              ..:|.|..|.|.. .:::|....||            .:..:.:..||..::.....|:....
Worm   307 --KSLDELRIGAPKK-DIMMGFAEHEGLFFEFLIKDPTPPLEALKLYVNEYYKKDTGDHFEATRN 368

  Fly   379 ELLEFPASFSQDRREKMMDLLVEVYFQGQHEVNELTVQGFMNLISDRGFKQPLYNTIHKNVCHTP 443
            :::||.:...:|..||.                  |.:..::.:.|..|...:::.. ||.....
Worm   369 KIIEFYSRNVEDTDEKS------------------TKERLIDFVGDALFTAGVFDNA-KNCLKHG 414

  Fly   444 NPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPLLFPDFQRNSTEAKVIHSFVD 508
            |.|:||.|:|..|..:.:..........   .||.||.|:.... |:.|||....|.|:|.....
Worm   415 NNVWLYIFDYCNPSGFGNQEEFMTFVAP---THCTDLRYVLGEG-LYSDFQPTEEEHKMIEKMTT 475

  Fly   509 YFVHFAKFGKPRNSES 524
            .:.:|||:|.|....|
Worm   476 IYSNFAKYGNPNEHGS 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	146/531 (27%)
cest-28	NP_504691.2	COesterase	17..516	CDD:278561	148/536 (28%)
cest-28	NP_504691.2	Aes	<112..>222	CDD:223730	49/112 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820