DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhe and cest-31

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_504692.3	Gene:	cest-31 / 187304	WormBaseID:	WBGene00019653	Length:	541	Species:	Caenorhabditis elegans

Alignment Length:	521	Identity:	161/521 - (30%)
Similarity:	246/521 - (47%)	Gaps:	64/521 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LTVCPPSVGCLKGTNLQGYQSERFEAFMGIPYALPPIGDLRFSNPK-----VMPKLLGMYDASAP 91
            |.|...:.|.::| ||..:.:|....::|||||.||||.|||..|.     ...:....|....|
Worm    14 LNVLNSTCGPVQG-NLYRHGNEEVHGYLGIPYAQPPIGILRFKKPVSADVWTETRDCTKYGPRCP 77

  Fly    92 KMDCIQKNYLLPTPVVYGDEDCLYLNVYRP--EIRKSAL-PVMVYIHGGGFFGGSAGPGVTGPEY 153
            ....:.:|..||...:..:.:||.|||:.|  ||::||. |||::||||||       .::..:.
Worm    78 PSGMLYENLQLPNTDIPDEANCLSLNVFCPQWEIKQSAKHPVMIFIHGGGF-------ELSASKD 135

  Fly   154 FMD---SG-----EVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQ 210
            :.|   ||     :||:||:.||:|..|||:|.|....|||||.|..|||:||..:|..|||||:
Worm   136 YCDYSLSGTLPLKDVIVVTVNYRVGALGFLTTGDDSCRGNFGLWDLTLALKWVSTHISSFGGDPK 200

  Fly   211 RVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLAEFADVPDARN 275
            .||:||||||.|.|.:..|||.|..|||::|.|||:|:|||||..:. .||.:..|:|.......
Worm   201 NVTLFGQSAGAVCADLLNLSPYSRDLFHKLIIMSGSAHVPFAIRTEE-NQALVCMEYARSRGFSG 264

  Fly   276 LSTVKLTKALRRINATKLLNAGDGLKYWDVDHMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPTS 340
            ..:.:|.:....:...|||.. .|||: .|....:|.|    .|:.|.|  ..|::.|.:.....
Worm   265 SGSAELLEFFENLPIEKLLEK-TGLKH-TVSIDLSFAP----NLDGDFF--PKPLEELRRETRKK 321

  Fly   341 IPLLLGTVPGEGAVRVVNILGNETLRQSFNLRFD-ELLQELLEFPASFSQDRREKMMDLLVEVYF 404
             |:::|.:..||.:.........|..::|..|.: |...:::|.|        |.:...::..|.
Worm   322 -PVIVGMMEDEGLITAFADGDFTTCEENFKRRVESEYRGDVVENP--------ENVQKNIMNFYT 377

  Fly   405 QGQHEVNELTVQGFMNLISDRGFKQPLYNT----IHKNVCHTPNPVYLYSFNYQGPLSYASAYTS 465
            ....|..|..:..::.        ..:||.    ..:::....|.||.|.|::..|..:...
Worm   378 NYCDESEERKLVDYIG--------HSVYNAGVLLSAESLARAGNCVYFYVFDFWNPDGFGPV--- 431

  Fly   466 ANVTGKYGVVHCDDLLYLFRSPLLFPDFQRNSTEAKVIHSFVDYFVHFAKFGKPR-----NSESL 525
            .::....|..||.:|.|:.... ::..|..|..:.|::......|.:|||:|.|.     |.|:.
Worm   432 GSIVPFKGAAHCSELRYIIGEG-VYSKFDANEKDLKMMEYMTTMFTNFAKYGNPNIPGVTNWETY 495

  Fly   526 T 526
            |
Worm   496 T 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	159/513 (31%)
cest-31	NP_504692.3	COesterase	16..522	CDD:278561	160/519 (31%)
cest-31	NP_504692.3	Aes	<112..>211	CDD:223730	50/105 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820