Protein Alignment Jhe and cest-8

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_001359583.1
• Gene: cest-8 / 182818
• WormBaseID: WBGene00007691
• Length: 605
• Species: Caenorhabditis elegans
• Alignment Length: 580
• Identity: 137/580 - (23%)
• Similarity: 218/580 - (37%)
• Gaps: 154/580 - (26%)

  Fly     6 MLQLLLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKGTNLQGYQSERFEAFMGIPYALPPIGD 70
            ::.:|||          |:.|.....|.:...|.|.|:|.......:.....|..:|:|.||||:
 Worm     2 LVSILLL----------CSLLYEFQTLKIINTSYGKLRGMAEWSDDANHKFTFKSVPFAKPPIGN 56

  Fly    71 LRFSNPKVMPKLLGMYDASAPKMDCIQKNYLLPTPVVYGDEDCLYLNVYRPE-IRKSALPVMVYI 134
            |||:.|:.:....|:.|||.....|:..:.|  |...|.:|||||:|::..| ..||...|:||.
 Worm    57 LRFAPPQKLDHWDGILDASVYSAACMSNSTL--TTQSYVNEDCLYINIFTSEKCLKSKCSVIVYF 119

  Fly   135 HGGGFFGGSAGPGVTGPEYFMD---SGEVILVTMAYRLGPFGFL-STQDAVMSGNFGLKDQNLAL 195
            |||.:...||  .:....:.:|   ..:||.|..|.|||.||.| ...:|.::.|..:.|..|||
 Worm   120 HGGAYNTESA--TMFSDRFILDRYVHEDVIFVIPAVRLGVFGQLYFGPNAYLTENLFMFDAILAL 182

  Fly   196 RWVQRNIRFFGGDPQRVTIFGQSAGGVAAH----MHLLSPRSHGLFHRVISMSGTANVPF--AIA 254
            .:|...|..|||||::|||.|.|:||....    ..::.|... ||.::|.:|.|....|  .:.
 Worm   183 DFVHNEISNFGGDPEKVTIMGHSSGGTLVEALGFSSMVDPELK-LFQQMIMLSSTGMFGFDDLVI 246

  Fly   255 EQPLEQARLLAEFADVPDARNLSTVKLTKAL---RRINATKLLNAGDGLKYWDVDHMTNFRPVVE 316
            :........|..|....:.||  ||.:.:.|   |.|:..::|.                   |:
 Worm   247 DNSFTIVEKLGCFNGTKEERN--TVNVAETLDCMRHIDGYEILR-------------------VQ 290

  Fly   317 EGLEVDAFLNAHPMDMLA-----QGMPTSIPLLLGTVPGEGAVRVVNILGNETLRQSFNLRFDEL 376
            :.:|:        ||.|:     :|.|  ..||.|        .:.::..|.:.|.:
 Worm   291 QKMEL--------MDQLSFKYLLRGAP--FMLLNG--------NIADLKKNTSPRNA-------- 329

  Fly   377 LQELLEFPASFSQDRREKMMDLLVEVYFQGQHEVNELTVQGFMNLISDRGFKQPLYNTIHKNVCH 441
                                     ::...:||..::|             ::.||.|:  ....
 Worm   330 -------------------------IFGTTEHEFFDVT-------------EKYLYITV--TFLD 354

  Fly   442 TPNPVYLYSFNYQGPLS--------------YASAYTSANVTGKYGV------------VHCDDL 480
            ..|||.: :.||.|.|.              :.|..|.|......|.            ||..|:
 Worm   355 YENPVAV-ARNYDGRLMKNMETMITGDSAAIFVSTATCAAAMANAGADVFLFETRQSYSVHVSDM 418

  Fly   481 LYLFRSPLLFPDFQRNSTEAKVIHSFVD-YFVHFAKFGKPRNS-ESLTPCSIEVLQSRPD 538
            .|...:...    ...:.:..::.||.. ...:|.|.|||... :.:.|..:..|:.:.|
 Worm   419 QYFIGNHCA----HNRTIDIDILDSFYSKLLTNFTKHGKPSPGWDPVDPGRMNYLELKVD 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	128/535 (24%)
cest-8	NP_001359583.1	alpha/beta hydrolases	19..495	CDD:473884	131/553 (24%)