Protein Alignment Jhe and cest-2.3

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_506510.2
• Gene: cest-2.3 / 179918
• WormBaseID: WBGene00013873
• Length: 665
• Species: Caenorhabditis elegans
• Alignment Length: 642
• Identity: 155/642 - (24%)
• Similarity: 245/642 - (38%)
• Gaps: 184/642 - (28%)

  Fly     6 MLQLLLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKGTNLQG----YQSERFEAFMGIPYALP 66
            :||.|....|:.      .:::|..||     |.|.::|..|..    :.::....|:||||..|
 Worm     2 ILQYLYFAVLIH------LSISTRIQL-----STGTIEGKILNATYSPFGNQTATVFLGIPYVEP 55

  Fly    67 PIGDLRFSNPKVMPKLLGMYDASAPKMDCIQ------KNYLLPTPVVYGD--EDCLYLNVYRPE- 122
            |||:|||..|:::....|:.:....|..|:.      ||..:      |:  |||||.||:..:
 Worm    56 PIGELRFRKPRLLKSWEGVLETKDYKPACMSYWRKTFKNGFV------GEISEDCLYANVFTNQY 114

  Fly   123 -IRKSALPVMVYIHGGGFF--GGSAGPGVTGPEYFMDS--GE---VILVTMAYRLGPFGFLSTQD 179
             ::.....||:.:|||...  .|||    ..||.|:::  |:   :::||..||||.|||
 Worm   115 CLQNKNCSVMIVVHGGRLVCESGSA----FKPEIFINNFVGQDRNIVVVTFNYRLGVFGF----- 170

  Fly   180 AVMSGNFGLKDQNLAL-------RWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLF 237
            .|.:|..|  |.|:|:       :||::.|..|||:..|:|:.|.|||.........|..|.||.
 Worm   171 GVFNGETG--DTNVAMYDMLEAVKWVRKEIDQFGGNKDRITMAGHSAGAGLIVDFTSSTLSKGLL 233

  Fly   238 HRVISMSGTANVPFAIAEQPLEQARLLAEFAD----------VPDA---RNLSTVKLTK---ALR 286
            |:.|.||.           ||:.....|.|..          :|..   |.||..::.|   .|:
 Worm   234 HQQIVMSA-----------PLQDISKSANFKGMTIVAQNVGCIPKEYGFRKLSKTQINKTYLCLQ 287

  Fly   287 RINATKLLNAGDGLKYWDVDHMTNFRPVVEEGLEVDA-FLNAHPMDMLAQGMPTSIPLLLGTVPG 350
            ..:|..||:|...::.....:..:.|        ||. |:..:|.::........|...:||..|
 Worm   288 NKSAQDLLHAQLSMQQNSTFYFGSPR--------VDGDFITDYPDNLFNFNTIYPINTFIGTTTG 344

  Fly   351 EGAVRVVNILGNETLRQSF------NLRFDELL---------QELLEFPASFSQDRREKMMDLLV 400
            |             ||.|.      |.|..|.|         .||.|.|..|::.
 Worm   345 E-------------LRDSLYITDPKNDRIKEQLLKNMCEHVGYELFEKPEEFTKK---------- 386

  Fly   401 EVYFQGQHEVNELTVQGFMNLISDRGFKQPLYN------TIHKNVCHTPNPVYLYSFNYQGPLSY 459
                .|.:..|....|    .:||   ....|:      ..||   ...:.|::||::|:|..:.
 Worm   387 ----CGNYYKNGTDAQ----FLSD---DMEFYSGAIKVANAHK---RANSKVFMYSYDYKGAGTA 437

  Fly   460 ASAYTSANVTGKYGVVHCDDLLYLF---RSPLLFPDFQRNSTEAKVIHSFVDYFVHFAKFGKPRN 521
            ...|..|.     ...|.:||:|.|   |.|.:..|:......:.::.:|:             |
 Worm   438 FHKYLEAP-----SPHHSEDLIYTFGTSRGPFVAKDYVIERIYSGMLANFI-------------N 484

  Fly   522 SESLTPCSIE-----VLQSRPDGICDYHEFANAPDAYQGFEVHVASEFQTDRVNLWS 573
            .|..:|...:     ..:.|...:.|:.:....|    |.:.|    :.|..::.||
 Worm   485 FEDPSPSKTQQWRQYTQEKREYFLIDFDKNFTMP----GMKDH----YYTRALDFWS 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	139/557 (25%)
cest-2.3	NP_506510.2	alpha/beta hydrolases	17..532	CDD:473884	149/618 (24%)