Protein Alignment Jhe and cest-1.2

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_506504.2
• Gene: cest-1.2 / 179914
• WormBaseID: WBGene00011364
• Length: 676
• Species: Caenorhabditis elegans
• Alignment Length: 498
• Identity: 135/498 - (27%)
• Similarity: 211/498 - (42%)
• Gaps: 90/498 - (18%)

  Fly    25 ALATVDQLTVCPPSVGCLKGTNLQG----YQSERFEAFMGIPYALPPIGDLRFSNPKVMPKLLGM 85
            |::|..||     |.|.::|..|..    :.::...||:||||..||||||||..|:......|:
 Worm    16 AISTKVQL-----STGIIEGKQLNSTYSPFGNQSAIAFLGIPYVEPPIGDLRFRKPRPQKTWSGV 75

  Fly    86 YDASAPKMDCIQ------KNYLLPTPVVYGDEDCLYLNVYRPE--IRKSALPVMVYIHGGGFFGG 142
            .:....|..|:.      ||..:..|:   .||||||||...:  :......|::.:||||:...
 Worm    76 LETKKFKPACMSNSTKTYKNGGIGGPI---SEDCLYLNVLTNQYCLENKNCSVVIIVHGGGYLFE 137

  Fly   143 SAGP---GVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRF 204
            ||..   .:....:......:::||:.||||.|||..........|.|:.|...|::||:|.|:.
 Worm   138 SAATFNHEILVNNFVGQDRNIVVVTINYRLGIFGFGHLNGFEGDKNVGIFDTLEAVKWVRREIKQ 202

  Fly   205 FGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSG-TANVPFAIAEQPLEQARLLAE-- 266
            |||:..|:|:.|.|||........:||.:.||.|:.|.||| ..|:.   .:...:....:||
 Worm   203 FGGNKDRITLAGHSAGAGVVAAFTISPLTKGLIHQQIVMSGPMTNMS---KKSNFKGMTAMAERV 264

  Fly   267 --------FADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVDHMTNF--RPVVEEGLEV 321
                    |..:|:.   ...::...||:..|.:||:|    :.|.:.:.|.:  .|.|:
 Worm   265 GCHSKKYGFNKLPEH---EVEQVYSCLRKKPAQELLDA----QLWLLQNSTFYFGAPPVD----- 317

  Fly   322 DAFLNAHPMDMLAQGMPTSIPLLLGTVPGE----GAVRVVNILGNETLRQSF--NLRFDELLQEL 380
            ..|:..:|.::.::....||..||||...|    |.:...|....|| :::|  || .|::..|:
 Worm   318 GEFITDYPDNLYSEKSIFSINTLLGTTTRELQDTGYISNSNYSKFET-KETFLKNL-CDQIGIEI 380

  Fly   381 LEFPASFSQDRREKMMDLLVEVYFQGQHEVNELTVQGFMNLISDRGFKQPLYNTIHKNVCHTPNP 445
            .:....|| .:.:|.       |..|...         .:|..|..|.....|....: ......
 Worm   381 YKESEDFS-SKCQKW-------YINGSDS---------KSLSDDMEFYTQAINLADAH-ARKGKK 427

  Fly   446 VYLYSFNYQGPLSYASAYTSANVTGKYGVV----HCDDLLYLF 484
            ||:||:.|.|         :.....||..|    |.:||:|.|
 Worm   428 VYMYSYAYSG---------AGPAFKKYMKVKSPHHSEDLIYTF 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	131/485 (27%)
cest-1.2	NP_506504.2	COesterase	18..536	CDD:395084	134/496 (27%)