Protein Alignment Jhe and cest-17

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_505114.1
• Gene: cest-17 / 179198
• WormBaseID: WBGene00019477
• Length: 571
• Species: Caenorhabditis elegans
• Alignment Length: 613
• Identity: 169/613 - (27%)
• Similarity: 254/613 - (41%)
• Gaps: 126/613 - (20%)

  Fly    10 LLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKGTNLQGYQSERFEAFMGIPYALPPIGDLRFS 74
            ||||..|..|. ||.:...|  .|...|.||....:.:.|   .::..|:||.|..||....||.
 Worm     6 LLLGYFLVSPA-FCVSKPKV--TTPYGPIVGFEHKSTVTG---SKYHVFLGIRYGNPPDHIYRFQ 64

  Fly    75 NPKVMPKLLGM-YDASAPKMDCI---------QKNYLLPTPVVYGDEDCLYLNVYR-PEIRKSAL 128
            .|:.:.|...: :||:..:..||         |.||         .||||:||:.. |:.::..|
 Worm    65 KPEPVEKWPHINHDATHFRASCIPSLRSELEEQVNY---------SEDCLFLNIVTPPDAKEKKL 120

  Fly   129 PVMVYIHGGGF-FGGSAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQN 192
            ||:|:|||||| ||.::..|.........|.::|.|::.|||||.||.:|.|:.:.||.||.||.
 Worm   121 PVLVFIHGGGFQFGDTSMIGYQKAADNFVSKDIIFVSIQYRLGPLGFFTTGDSEIPGNMGLWDQT 185

  Fly   193 LALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQP 257
            |||:::...:..|||||.|:|:.|.|||..:....|.||.|..||.:.|.:||:......:....
 Worm   186 LALQFLHEVLPDFGGDPDRITLAGHSAGAASVSALLYSPHSDHLFSQAIQLSGSIFSESNLDRNV 250

  Fly   258 LEQARLLAEFADVP--------DARNLSTV-KLTKALRRINATKLLNAGDGLK----YWDVDHMT 309
            ::.:|.||:.|..|        |...:.|| :|..|:..|..   |..|...|    |:|.|
 Worm   251 VDDSRKLAKAAGCPQEDSKELRDCIEIRTVDELLDAMESIGE---LLPGPRTKKFHPYFDKD--- 309

  Fly   310 NFRPVVEEGLEVDAFLNAHPMDMLAQGM-----------PTSIPLLLGTVPGEGAVRVVNILGNE 363
             |.|     .:::......|.....||:           |..:..||| ||
 Worm   310 -FFP-----YDIEKMSRKAPKKRTMQGLVSLESGLSVLYPVKLAKLLG-VP-------------- 353

  Fly   364 TLRQSFNLRFDELLQELLEFPASFSQD---RREKMMDLLVEVYFQGQHEVN-ELTVQGFMNLISD 424
              ::|::....:.|.:.:....:..|:   ...:...|:.|.|..|....| ...:..|.||:||
 Worm   354 --KESWSTYSKDNLVDFIRSQVAVEQEFGTASARFSGLVEEFYLSGPMTGNSSFYLNAFANLLSD 416

  Fly   425 RGFKQPLYNTIHKNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKY-GVVHCDDLLYLFR--- 485
            ..:..|..:.:...:.|..: .|||..:|       .:.|:.:.|... |..|..:|.|||.
 Worm   417 LQYNIPTLHEVELKLQHGWD-TYLYIIDY-------DSETTKDPTHPIKGPFHASELRYLFNFNG 473

  Fly   486 -SPLLFPDFQRNSTEAKVIHSFVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICDYHEFAN- 548
             ..:.|     |..:.|..:.||:..|:|...|.|.....|.|.   |.:|:|        |||
 Worm   474 MDTIPF-----NDKDKKFENYFVNAIVNFINTGTPSTKALLWPA---VSKSQP--------FANL 522

  Fly   549 ----APDAYQGFEVHVASEFQTDRVNLW 572
                .|.        |.:.|:.:...||
 Worm   523 LLNDKPS--------VQTSFRQEAYELW 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	146/533 (27%)
cest-17	NP_505114.1	COesterase	22..542	CDD:395084	159/594 (27%)