DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhe and cest-24

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_504613.1	Gene:	cest-24 / 179017	WormBaseID:	WBGene00020891	Length:	658	Species:	Caenorhabditis elegans

Alignment Length:	610	Identity:	168/610 - (27%)
Similarity:	253/610 - (41%)	Gaps:	147/610 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ALATVDQLTVCPPSVGCLKGTNLQGYQSERFEAFMGIPYALPPIGDLRFSNPKVMPKLLGMYDAS 89
            |:..|.|        |.|:|..::..:.:..:.|.|||||.||:|:|||..|:......|:...:
Worm    96 AIVRVQQ--------GLLEGFRVKTAKGDLCDVFHGIPYAEPPVGELRFQKPQPPKAWEGIRKCN 152

  Fly    90 APKMDCIQKNYLLP----TPVVYGDEDCLYLNVYRPEIRK-SALPVMVYIHGGGFFGGSAGPGVT 149
            ......|.|.  :|    .|.....||||||||:.|:||: ...||:.||||||:...||
Worm   153 KYPNRSIHKE--MPWDKALPSANQSEDCLYLNVFAPKIREDKKYPVLFYIHGGGYVMDSA----- 210

  Fly   150 GPEY-------FMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGG 207
             ..|       .:.|.|:|:||..||||..|||||.|.|..||:||.|...|:|||..||..|||
Worm   211 -ERYTAKNICKLLVSREIIVVTFHYRLGFLGFLSTGDDVCPGNYGLFDMLEAMRWVHANISSFGG 274

  Fly   208 DPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLAEFADVPD 272
            ||:.:|:.|||||..||.:...||.:.|||.|.|.|.|.:...:|....           .|:.:
Worm   275 DPENITLSGQSAGAAAADLLSFSPLTKGLFKRKIVMGGNSYCHWATTSN-----------HDIRE 328

  Fly   273 -----ARNLS-TVKLTKALRRINATKLLNAGDGLKYWDVDHMTNF-------------RPVVEEG 318
                 |:.|. ..:|..|.:|..:..:.|..:||....:. ||.|             .||
Worm   329 YCKKWAKRLGWKPQLNYANKREESVDIFNFFNGLPTSKLG-MTMFFSNTIFKECQLPLAPV---- 388

  Fly   319 LEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGE---------GAVR--------VVNILGNET-L 365
              :|..:..|.:.:|.: ....:|.|:|  .||         |.:|        .:::|..:. |
Worm   389 --IDGEILPHDLKVLRE-TQEHVPSLVG--GGEYEALLFCAIGLLRGTEKEINSAIDVLSRKNRL 448

  Fly   366 RQSFNLRFDELLQELL-EFPASFSQDRREKM--MDLLVEVYFQ-GQHEVNELTVQGFMNLISDRG 426
            .:|   :.:.:.:::. :.||..:..:..||  :.|:.:::.. |.:.        ||.....||
Worm   449 SRS---KIEAMTEKVYGDSPALRADSKARKMFFVQLISDIFANYGNYR--------FMRDCQQRG 502

  Fly   427 FKQPLYNTIHKNVCHTPNPVYLYSFNYQ-----GPLSYASAYTSANVTGKYGVVHCDDLLYLFRS 486
            .:           |      |.|||::|     |.|.:...:|        |..|..:|.|||..
Worm   503 VE-----------C------YGYSFDHQSKQMWGWLQHVVPFT--------GGTHTSELSYLFDC 542

  Fly   487 PLLFPDFQRNSTEAKVIHSFVDYFVHFAKFGKPRNSESLTPC---------SIEVLQSRPDGICD 542
            ..:......|.|:..|.....|||.:|.|||.|....|..|.         .::::..:|:
Worm   543 NYMSAPLGMNKTDKVVSGMTADYFTNFVKFGTPNGPNSQLPKWERISPDDEHMKLISIKPE---- 603

  Fly   543 YHEFANAPDAY--QGFEVHVASEFQ 565
             .|.......|  |.||.|:...::
Worm   604 -PEMKTTVYGYRMQNFEDHLGMLYE 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	157/544 (29%)
cest-24	NP_504613.1	COesterase	97..608	CDD:278561	162/588 (28%)
cest-24	NP_504613.1	Aes	<183..>285	CDD:223730	49/107 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020