DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhe and cest-27

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_871861.2	Gene:	cest-27 / 171610	WormBaseID:	WBGene00018958	Length:	561	Species:	Caenorhabditis elegans

Alignment Length:	607	Identity:	174/607 - (28%)
Similarity:	255/607 - (42%)	Gaps:	136/607 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LATVDQLTVCPPSVGCLKGTNLQGYQSER---FEAFMGIPYALPPIGDLRFSNPKVMPKLLGMYD 87
            |..|...| |.|    :||.   ||:.|.   .|.|:|||||.||||.|||..|....|.
Worm    24 LTAVHDAT-CGP----IKGV---GYEQEDGSVVEGFLGIPYAEPPIGALRFKKPVAHRKW----- 75

  Fly    88 ASAPKMDCI-------QKNYLL---PTPVVYGDEDCLYLNVYRPEIRKS----ALPVMVYIHGGG 138
              ...:||:       |.:.||   ...|...:|.||.|||:.|:...:    ..||||:|||||
Worm    76 --TEPLDCVRFGPRSPQNDELLGQFVNTVGKSEEHCLSLNVFTPKWESNEWPDGFPVMVFIHGGG 138

  Fly   139 F-FGGSAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNI 202
            | ...|:..|.......:.:.:|::||:.||||..||.:|.|.|..||.||.||..||.|||.||
Worm   139 FAVHSSSNYGCASIARNLCTKDVVVVTINYRLGVLGFFTTGDEVCRGNLGLWDQTAALEWVQENI 203

  Fly   203 RFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAI--AEQPLEQARLLA 265
            :.|.|||..||||||||||.:..:..|||.|.|||:|.|.|:|.....||:  :||   ||:|..
Worm   204 QSFRGDPDNVTIFGQSAGGASVDLLCLSPHSRGLFNRAIPMAGNGECDFAMRTSEQ---QAQLSR 265

  Fly   266 EFA-------DVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVDHM---TNFRPVVEEGLE 320
            |||       |..|:.:|......:.|.:|...  :|...|.|:.....:   .||
Worm   266 EFARYLGWEGDDNDSEDLLQFIDQQPLYKIEMG--INPKRGFKHSQAGSLYFVPNF--------- 319

  Fly   321 VDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVV------------NILGNETLRQSFNLRF 373
             |......|::.|.:..| .:.::.||...||...:.            ..:|.......:..|.
Worm   320 -DGDFFPKPLNQLRKEAP-KMQIMTGTTKYEGLFFIALGALSKNPEGIKKFMGRIFKECDYGERA 382

  Fly   374 DELLQELLEFPASFSQDRREKMMDLLVEVYFQGQH-EVNELTVQGFMNLISDRGFKQPLYN--TI 435
            |::||.:.:|                   ||:|.| :.:|..:...:..|.|.......|.  .|
Worm   383 DDVLQMVYDF-------------------YFKGVHPKDHEKNMHQIVKFIGDYSINYGTYRLANI 428

  Fly   436 HKNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKY-------GVVHCDDLLYLFRSPLLFPDF 493
            ..::.|   .||.|.|:|.....:          |.:       |..||.::.|:....:: ..|
Worm   429 MTDLQH---DVYFYQFDYHNSAGF----------GVFRWLLPFLGSTHCTEMRYVLGKGII-SKF 479

  Fly   494 QRNSTEAKVIHSFVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICDYHEFANAPDAYQGFEV 558
            :.|..:.|::|....||.:|||:|.|..            :::..|....|:.|:   .::.|::
Worm   480 RPNDNDKKMLHVMTTYFTNFAKYGNPNG------------ENQETGEWQKHDSAH---PFRHFKI 529

  Fly   559 -----HVASEFQTDRVNLWSHI 575
                 .:..::|..|..||..:
Worm   530 DLDDSEMVEDYQERRAELWDKL 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	161/538 (30%)
cest-27	NP_871861.2	COesterase	29..541	CDD:278561	168/590 (28%)
cest-27	NP_871861.2	Aes	<114..>283	CDD:223730	76/171 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157225
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850