DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhe and Ces2c

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_598270.2	Gene:	Ces2c / 171118	RGDID:	621510	Length:	561	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	164/556 - (29%)
Similarity:	242/556 - (43%)	Gaps:	102/556 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 FMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDCIQ-------------KNYLLPTPVVYG 109
            |:|||:|..|:|.|||:.|:......|:.|.::....|:|             |..|...|:
  Rat    60 FLGIPFAKAPVGPLRFAPPEDPEPWSGVRDGTSHPAMCLQNIDMLDEVGLTDMKMILSSIPM--- 121

  Fly   110 DEDCLYLNVYRP--EIRKSALPVMVYIHGGGFFGGSAGPGVTGPEYFMDSG-------EVILVTM 165
            .|||||||:|.|  ....|.|||||.||||....|.|.         |..|       ::::|.:
  Rat   122 SEDCLYLNIYTPAHAHEGSNLPVMVCIHGGALVIGMAS---------MCDGSLLAVNEDLVVVAI 177

  Fly   166 AYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLS 230
            .||||..||.||.|....||:|..||..||||||:||..|||:|.||||||.||||.:...|::|
  Rat   178 QYRLGVLGFFSTGDEHARGNWGYLDQVAALRWVQQNIAHFGGNPNRVTIFGVSAGGTSVSSHVIS 242

  Fly   231 PRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLAEFA--DVPDARNLSTVKLTKALRRINATKL 293
            |.|.||||..|..||.|.:|..|:|.....:..:|:.:  :..|:..|              .:.
  Rat   243 PMSQGLFHGAIMESGVALLPDLISETSETVSTTVAKLSGCEATDSETL--------------VRC 293

  Fly   294 LNAGDGLKYWDVDHMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVN 358
            |.|..|.:...::.:....|.|.:|    .||..||.::||......:|.::|....|....:..
  Rat   294 LRAKSGAEILVINKVFKMIPAVVDG----EFLPRHPKELLASEDFHPVPSIIGVNTDEYCCTIPM 354

  Fly   359 ILGNETLRQSFNLRFDELLQELLEFPASFSQDRREKMM------DLLVEVYFQGQHEVNELTVQG 417
            ::|...:       ..||.:|.|:   :..:|...:||      |||:|.|.....:...|.:|
  Rat   355 VMGTAQI-------IKELSRENLQ---AVLKDTAAQMMLPPECGDLLMEEYMGNTDDPQTLQIQ- 408

  Fly   418 FMNLISDRGFKQPLYNTIHKNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLY 482
            :..::.|..|..|.....|....|.  |||.|.|.: .| ||.......:|...    |.|::.:
  Rat   409 YAEMMGDFLFVIPALQVAHFQRSHA--PVYFYEFQH-AP-SYFKNVRPPHVKAD----HADEVPF 465

  Fly   483 LFRSPLLFPDFQRNSTEAKVIHS--FVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICDYHE 545
            :|.|  .|...:.:.||.:.:.|  .:.|:.:||:.|.| |||.|                .|..
  Rat   466 VFGS--FFWGIKVDFTEEEKLLSRRMMKYWANFARHGNP-NSEGL----------------PYWP 511

  Fly   546 FANAPDAYQGFEVHVASE--FQTDRVNLWSHILNEK 579
            ..:..:.|...:...|.:  .:..|:..|:..|.:|
  Rat   512 VLDHDEQYLQLDTQPAVDRALKARRLQFWTKTLPQK 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	157/500 (31%)
Ces2c	NP_598270.2	COesterase	32..540	CDD:395084	161/547 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920