DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhe and Ces3b

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_653094.2	Gene:	Ces3b / 13909	MGIID:	3644960	Length:	571	Species:	Mus musculus

Alignment Length:	602	Identity:	181/602 - (30%)
Similarity:	254/602 - (42%)	Gaps:	112/602 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 CAALATVDQLT---VCPPSV----GCLKGTNLQGYQSERF-EAFMGIPYALPPIGDLRFSNPKVM 79
            |..||.|..:|   |..|.|    |.::|..:....::|. ..|:|||:|..|:|.||||.|...
Mouse    20 CLLLAFVTTVTGPKVIQPEVDTPLGRVRGRQVGVKDTDRMVNVFLGIPFAQAPVGPLRFSAPLPP 84

  Fly    80 PKLLGMYDASAPKMDCIQ--------------KNYLLPTPVVYGDEDCLYLNVYRP-EIRK-SAL 128
            ....|:.|||.....|:|              |..:.|.     .||||.||:|.| ||.. ...
Mouse    85 QPWEGVRDASINPPMCLQDVEKMINSRFGLNEKIKIFPI-----SEDCLTLNIYSPTEITAGDKR 144

  Fly   129 PVMVYIHGGGFFGGSA----GPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLK 189
            ||||:||||....||:    |..:..      .|:|::||:.||||.||||||.|..|.||.|..
Mouse   145 PVMVWIHGGSLLVGSSTSQDGSALAA------YGDVVVVTVQYRLGIFGFLSTGDKHMPGNRGFL 203

  Fly   190 DQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIA 254
            |...||||||.||..|||||..|||||.||||:......|||.|.|||||.||.||.........
Mouse   204 DVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGMIVSSLFLSPISAGLFHRAISQSGIVTTIMMED 268

  Fly   255 EQPLEQARLLAEFADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVDHMTNFRPVVEEGL 319
            .:|..:|:   .||:.....:.|..:|.:.|.:.....|:..    |..::.::.|
Mouse   269 MKPWPEAQ---NFANSVACGSASPAELVQCLLQKEGKDLIKQ----KNVNISYIVN--------- 317

  Fly   320 EVDAFLNAHPMDMLA-QGMPTSIPLLLGTVPGEGA---VRVVNILGN-ETLRQSFNLRFDELLQE 379
              |:|....|..:|| |..|| :|.|||....|..   ::.:|||.. |.|.:...|........
Mouse   318 --DSFFPQRPEKLLADQQFPT-VPYLLGVTNHEFGWLLLKSLNILDKLEHLSREDLLEISRPFLA 379

  Fly   380 LLEFPASFSQDRREKMMDLLVEVYFQGQHEVNELTVQGFMNLISDRGFKQPLYNTIHKNVCHTPN 444
            ::|.|        .::|..:::.|.....: ...|...|..|:.|..|..|..| ..|.:.....
Mouse   380 IMEVP--------PEIMPTVIDEYLDNGSD-QSATRYAFQELLGDISFIIPTLN-FSKYLRDAGC 434

  Fly   445 PVYLYSFNYQGPLSYAS---AYTSANVTGKYGVVHCDDLLYLFRSPLL--------FPDFQRNST 498
            ||:||.|.:. |.|:|.   |:..|:        |..:..::|..|.|        ||  :....
Mouse   435 PVFLYEFQHT-PSSFAKFKPAWVKAD--------HASENSFVFGGPFLTDESSLLAFP--EATEE 488

  Fly   499 EAKVIHSFVDYFVHFAKFGKPRNSESLTPC-SIEVLQSRPDGICDYHEFANAPDAYQGFEVHVAS 562
            |.::..:.:..:..||:.|.| |.:.|.|. .:..|:       .|.|.        |.|.....
Mouse   489 EKQLSLTMMAQWSQFARTGNP-NGKGLPPWPQLNQLE-------QYLEI--------GLESRTGV 537

  Fly   563 EFQTDRVNLWSHILNEK 579
            :.:..|:..|:..|..|
Mouse   538 KLKKGRLQFWTETLPRK 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	163/523 (31%)
Ces3b	NP_653094.2	COesterase	36..547	CDD:278561	172/577 (30%)
		Aes	75..>245	CDD:223730	77/180 (43%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832478
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840