DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhe and Ces1c

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_031980.2	Gene:	Ces1c / 13884	MGIID:	95420	Length:	554	Species:	Mus musculus

Alignment Length:	600	Identity:	166/600 - (27%)
Similarity:	264/600 - (44%)	Gaps:	127/600 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LTVC--------PPSVGCLKGTNLQGYQS-ERFE----AFMGIPYALPPIGDLRFSNPKVMPKLL 83
            |.||        ||.|...:|..|..|.| |.||    .|:|:|:|.||:|.|||:.|:......
Mouse    11 LAVCPILGHSLLPPVVDTTQGKVLGKYISLEGFEQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWS 75

  Fly    84 GMYDASAPKMDCIQ--------------KNYLLPTPVVYGDEDCLYLNVYRP-EIRKSA-LPVMV 132
            .:.:|::....|.|              :..:||..:   .|||||||:|.| ::.||: |||||
Mouse    76 FVKNATSYPPMCSQDAGWAKILSDMFSTEKEILPLKI---SEDCLYLNIYSPADLTKSSQLPVMV 137

  Fly   133 YIHGGGFFGGSAGP----GVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNL 193
            :|||||...|.|.|    .::..|      .|::||:.||||.:|..||.|....||:...||..
Mouse   138 WIHGGGLVIGGASPYNGLALSAHE------NVVVVTIQYRLGIWGLFSTGDEHSPGNWAHLDQLA 196

  Fly   194 ALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPL 258
            ||||||.||..|||:|..|||||:|:||::..:.:|||....||||.||.||.. :...:.::.:
Mouse   197 ALRWVQDNIANFGGNPDSVTIFGESSGGISVSVLVLSPLGKDLFHRAISESGVV-INTNVGKKNI 260

  Fly   259 EQARLLAEFADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVDHMTNFRPVVEEGLEVDA 323
            :....:  .|.:....:.|:..:.:.||:...::||.....|..:::...|....||
Mouse   261 QAVNEI--IATLSQCNDTSSAAMVQCLRQKTESELLEISGKLVQYNISLSTMIDGVV-------- 315

  Fly   324 FLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNETLRQSFNLRFDELLQELL------E 382
             |...|.::||:....::|.::|          .|       :|.|......:||.||      |
Mouse   316 -LPKAPEEILAEKSFNTVPYIVG----------FN-------KQEFGWIIPMMLQNLLPEGKMNE 362

  Fly   383 FPASFSQDR-------REKMMDLLVEVYFQGQHE---VNELTVQGFMNLISDRGFKQPLYNTIHK 437
            ..||....|       .|.|:..::|.|.:|..:   .:||    .:::..|..|..|.. .:.:
Mouse   363 ETASLLLRRFHSELNISESMIPAVIEQYLRGVDDPAKKSEL----ILDMFGDIFFGIPAV-LLSR 422

  Fly   438 NVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPLLFPDFQRNSTE-AK 501
            ::.......|:|.|.|:.  |:.|......|.|.:|    |::.::|.:|||........|. :|
Mouse   423 SLRDAGVSTYMYEFRYRP--SFVSDKRPQTVEGDHG----DEIFFVFGAPLLKEGASEEETNLSK 481

  Fly   502 VIHSFVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICDYHEFANAPDAYQGF-----EVHVA 561
            ::..|   :.:||:.|.|..                :|:..:.|:    |..:|:     ....|
Mouse   482 MVMKF---WANFARNGNPNG----------------EGLPHWPEY----DEQEGYLQIGATTQQA 523

  Fly   562 SEFQTDRVNLWSHIL 576
            ...:.:.|..|:.:|
Mouse   524 QRLKAEEVAFWTELL 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	152/528 (29%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	158/571 (28%)
		Aes	<121..>234	CDD:223730	54/118 (46%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832547
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850