DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhe and Ces1g

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_067431.2	Gene:	Ces1g / 12623	MGIID:	88378	Length:	565	Species:	Mus musculus

Alignment Length:	614	Identity:	169/614 - (27%)
Similarity:	270/614 - (43%)	Gaps:	133/614 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ALATVDQLTVC--------PPSVGCLKG------TNLQGYQSERFEAFMGIPYALPPIGDLRFSN 75
            ||:.: .||.|        ||.|..:.|      ..|:|: |:....|:|:|:|.||:|.|||:.
Mouse     5 ALSLI-SLTACLSLGHPSLPPVVHTVHGKVLGKYVTLEGF-SQPVAVFLGVPFAKPPLGSLRFAP 67

  Fly    76 PK-VMPKLLGMYDASAPKMDCIQ--------------KNYLLPTPVVYGDEDCLYLNVYRPE--I 123
            |: ..|.....:..|.|.: |.|              :..::|...   .|||||||:|.|.  .
Mouse    68 PEPAEPWSFVKHTTSYPPL-CYQNPEAALRLAELFTNQRKIIPHKF---SEDCLYLNIYTPADLT 128

  Fly   124 RKSALPVMVYIHGGGFF--GGSAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNF 186
            :.|.|||||:|||||..  |.|...||  |....::  |::|.:.||||.:||.||:|....||:
Mouse   129 QNSRLPVMVWIHGGGLVIDGASTYDGV--PLAVHEN--VVVVVIQYRLGIWGFFSTEDEHSRGNW 189

  Fly   187 GLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVP- 250
            |..||..||.|||.||..|||:|..|||||:||||.:..:.:|||.:..||||.|:.|.....|
Mouse   190 GHLDQVAALHWVQDNIANFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAIAQSSVIFNPC 254

  Fly   251 -FAIAEQPLEQARLLAEFADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVDHMTN---- 310
             |..|.:||  |:.:|..|   ..:..::..:...||:....:||.....:|:..||.:.:
Mouse   255 LFGRAARPL--AKKIAALA---GCKTTTSAAMVHCLRQKTEDELLEVSLKMKFGTVDFLGDPRES 314

  Fly   311 --FRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNETLRQSFNLRF 373
              |.|.|.:|:    .|...|.::||:....::|.::|....|                     |
Mouse   315 YPFLPTVIDGV----LLPKAPEEILAEKSFNTVPYMVGINKHE---------------------F 354

  Fly   374 DELLQELLEFPASFSQ-DRR----------------EKMMDLLVEVYFQGQHEVNELTVQGFMNL 421
            ..::...|:||.|..: |::                ||::...:|.|..|..:...:| ..|::|
Mouse   355 GWIIPMFLDFPLSERKLDQKTAASILWQAYPILNISEKLIPAAIEKYLGGTEDPATMT-DLFLDL 418

  Fly   422 ISDRGFKQP--LYNTIHKNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLF 484
            |.|..|..|  :.:..|::   ...|.|:|.:.|:.  |:.|......:.|.    |.|:|..::
Mouse   419 IGDIMFGVPSVIVSRSHRD---AGAPTYMYEYQYRP--SFVSDDRPQELLGD----HADELFSVW 474

  Fly   485 RSPLLFPDFQRNSTEAKVIHS--FVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICDYHEFA 547
            .:|.|    :..::|.::..|  .:.::.:||:.|.|..                :|:..:.|:.
Mouse   475 GAPFL----KEGASEEEINLSKMVMKFWANFARNGNPNG----------------EGLPHWPEYD 519

  Fly   548 NAPDAYQ-GFEVHVASEFQTDRVNLWSHI 575
            ......| |.....|...:...|:.|:.:
Mouse   520 QKEGYLQIGVPAQAAHRLKDKEVDFWTEL 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	154/540 (29%)
Ces1g	NP_067431.2	COesterase	24..545	CDD:278561	162/589 (28%)
Ces1g	NP_067431.2	Aes	<121..>239	CDD:223730	57/121 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832553
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850