Protein Alignment Jhe and Nlgn2

DIOPT Version :9

• Sequence 1: NP_001163166.1
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_446444.1
• Gene: Nlgn2 / 117096
• RGDID: 621118
• Length: 836
• Species: Rattus norvegicus
• Alignment Length: 582
• Identity: 167/582 - (28%)
• Similarity: 264/582 - (45%)
• Gaps: 108/582 - (18%)

  Fly    58 FMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDCIQKNY-LLPT---PVVYGD-------- 110
            |:|:|||.||:|..||..|:......|:.:|:.....|.|..: .||.   ||.:.|
  Rat    69 FLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATY 133

  Fly   111 -----EDCLYLNVYRP--------------------EIRKSA-LPVMVYIHGGGFFGGSAG--PG 147
                 |||||||:|.|                    :||.|. .|||:::|||.:..|:..  .|
  Rat   134 VQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDG 198

  Fly   148 VTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRV 212
            .....|    |.||:.|:.||||..|||||.|....||:||.||..||||:..||..|||||:|:
  Rat   199 SVLAAY----GNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERI 259

  Fly   213 TIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLAEFADVPDARNLS 277
            ||||..||....::.:||..|.|||.:.|:.||||...:::..|||:..||||  |.|...|..|
  Rat   260 TIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLA--AKVGCDREDS 322

  Fly   278 TVKLTKALRRINATKLLNAGDGLKYWDVD----HMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMP 338
            | :..:.|||.::.:|::.       ||.    |:. |.|||:..:..|     .|..::.||..
  Rat   323 T-EAVECLRRKSSRELVDQ-------DVQPARYHIA-FGPVVDGDVVPD-----DPEILMQQGEF 373

  Fly   339 TSIPLLLGTVPGEGAVRVVNILGNE--TLRQSFNLRFDELLQELLEFPASFSQDRREKMMDLLVE 401
            .:..:|:|...|||...|.:...:|  ....:|:......:..|..:|     :.::.:.:.:..
  Rat   374 LNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVDNLYGYP-----EGKDVLRETIKF 433

  Fly   402 VYFQ-GQHEVNELTVQGFMNLISDRGFKQPLYNT--IHKNVCHTPNPVYLYSFNY----QGPLSY 459
            :|.. ...:..|:..:..:.|.:|..:..|...|  :|.:.   .:|||.|:|.:    :|...:
  Rat   434 MYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADY---QSPVYFYTFYHHCQAEGRPEW 495

  Fly   460 ASAYTSANVTGKYGVVHCDDLLYLFRSPL-----LFP-DFQRNSTEAKVIHSFVDYFVHFAKFGK 518
            |.|            .|.|:|.|:|..|:     ||| :|.:|......:  .:.|:.:|||.|.
  Rat   496 ADA------------AHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAV--VMTYWTNFAKTGD 546

  Fly   519 PRNSESLTPCSIEVLQSRPDGICD--YHEFANAPDAYQ--GFEVHVASEFQTDRVNLWSHIL 576
            |...   .|...:.:.::|:...:  :.:|.:....|.  |.:..|...::.::|..|..::
  Rat   547 PNQP---VPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELV 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	159/527 (30%)
Nlgn2	NP_446444.1	COesterase	42..601	CDD:395084	166/576 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336407
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840