DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhe and Ache

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	XP_036020624.1	Gene:	Ache / 11423	MGIID:	87876	Length:	616	Species:	Mus musculus

Alignment Length:	538	Identity:	161/538 - (29%)
Similarity:	233/538 - (43%)	Gaps:	107/538 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LKGTNLQGYQSER----FEAFMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDCIQ-KNYL 101
            ::|..|:|.:.:.    ..||:|||:|.||:|..||..|:......|:.||:..:..|.| .:.|
Mouse    43 VRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTL 107

  Fly   102 LP--------TPVVYGDEDCLYLNVYRPEIR-KSALPVMVYIHGGGFFGGSAGPGVTGPEYFMDS 157
            .|        .|.....||||||||:.|..| .|..||:::|:||||:.|:|...|....:....
Mouse   108 YPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQV 172

  Fly   158 GEVILVTMAYRLGPFGFLS---TQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSA 219
            ...:||:|.||:|.||||:   :::|  .||.||.||.|||:|||.||..|||||..||:||:||
Mouse   173 EGAVLVSMNYRVGTFGFLALPGSREA--PGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESA 235

  Fly   220 GGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAI--AEQPLEQARLLAEFADV-PDARNLSTVKL 281
            |..:..||:||..|..||||.:..|||.|.|:|.  |.:...:|.|||..... |.....:..:|
Mouse   236 GAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTEL 300

  Fly   282 TKALRRINATKLLNAGDGLKYWDVDH-----------MTNFRPVVEEGLEVDAFLNAHPMDMLAQ 335
            ...||...|..|           |||           ..:|.|||:     ..||:..|..::..
Mouse   301 IACLRTRPAQDL-----------VDHEWHVLPQESIFRFSFVPVVD-----GDFLSDTPEALINT 349

  Fly   336 GMPTSIPLLLGTVPGEGAVRVV-NILGNETLRQSFNLRFDELLQELLEFPASFSQDRREKMMDLL 399
            |....:.:|:|.|..||:..:| .:.|.....:|...|...|....:..|         :..||.
Mouse   350 GDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVP---------QASDLA 405

  Fly   400 VEV----YFQGQHEVNELTVQGFMN-LISDRGFKQPLYNTIHKNVCHTPN----------PVYLY 449
            .|.    |....|..:...::..|: ::.|           |..||....          .||.|
Mouse   406 AEAVVLHYTDWLHPEDPTHLRDAMSAVVGD-----------HNVVCPVAQLAGRLAAQGARVYAY 459

  Fly   450 SFNYQG-----PLSYASAYTSANVTGKYGVVHCDDLLYLFRSPLLFPDFQRNSTEAKVIHSFVDY 509
            .|.::.     ||             ..||.|..::.::|..| |.|.....:.|.......:.|
Mouse   460 IFEHRASTLTWPL-------------WMGVPHGYEIEFIFGLP-LDPSLNYTTEERIFAQRLMKY 510

  Fly   510 FVHFAKFG---KPRNSES 524
            :.:||:.|   .||:|:|
Mouse   511 WTNFARTGDPNDPRDSKS 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	161/538 (30%)
Ache	XP_036020624.1	COesterase	37..563	CDD:395084	161/538 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832818
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840