DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhe and Ces1d

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_579829.3	Gene:	Ces1d / 113902	RGDID:	70896	Length:	565	Species:	Rattus norvegicus

Alignment Length:	599	Identity:	173/599 - (28%)
Similarity:	261/599 - (43%)	Gaps:	132/599 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PPSVGCLKG------TNLQGYQSERFEAFMGIPYALPPIGDLRFSNPK-VMPKLLGMYDASAPKM 93
            ||.|..:||      .||:|: ::....|:|||:|.||:|.|||:.|: ..|........|.|.|
  Rat    23 PPVVNTVKGKVLGKYVNLEGF-AQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWNFVKNTTSYPPM 86

  Fly    94 DCIQ------------KNYLLPTPVVYGDEDCLYLNVYRPE--IRKSALPVMVYIHGGGFFGGSA 144
             |.|            .|.....|:.: .|||||||||.|.  .:.|.|||||:|||||...|.|
  Rat    87 -CSQDAVGGQVLSELFTNRKENIPLQF-SEDCLYLNVYTPADLTKNSRLPVMVWIHGGGLVVGGA 149

  Fly   145 ----GPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFF 205
                |..::..|      .|::||:.||||.:||.||.|....||:|..||..||.|||.||..|
  Rat   150 STYDGQVLSAHE------NVVVVTIQYRLGIWGFFSTGDEHSQGNWGHLDQVAALHWVQDNIANF 208

  Fly   206 GGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLAEFADV 270
            ||:|..|||||:||||.:....:|||.:..||||.||.||.......|.......|.|:|..:
  Rat   209 GGNPGSVTIFGESAGGFSVSALVLSPLAKNLFHRAISESGVVLTSALITTDSKPIANLIATLS-- 271

  Fly   271 PDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVDHMTN------FRPVVEEGLEVDAFLNAHP 329
             ..:..::..:...||:....:||.....|..:.:|.:.|      |.|.|.:|:    .|...|
  Rat   272 -GCKTTTSAVMVHCLRQKTEDELLETSLKLNLFKLDLLGNPKESYPFLPTVIDGV----VLPKTP 331

  Fly   330 MDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNETLRQSFNLRFDELLQELLEFPASFSQ-DRR- 392
            .::|.:....::|.::|          :|       :|.|..    ::..|:.:|.|..: |::
  Rat   332 EEILTEKSFNTVPYIVG----------IN-------KQEFGW----IIPTLMGYPLSEGKLDQKT 375

  Fly   393 ---------------EKMMDLLVEVYFQGQHEV---NELTVQGFMNLISDRGFKQP--LYNTIHK 437
                           |||:.::.|.||.|..:.   .:|    |.:|::|..|..|  :.:..|:
  Rat   376 AKSLLWKSYPTLKISEKMIPVVAEKYFGGTDDPAKRKDL----FQDLVADVMFGVPSVMVSRSHR 436

  Fly   438 NVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPLLFPDFQRNSTE-AK 501
            :   ...|.::|.|.|:.  |:.||.....|.|.:|    |:|..:|.||.|........|. :|
  Rat   437 D---AGAPTFMYEFEYRP--SFVSAMRPKTVIGDHG----DELFSVFGSPFLKDGASEEETNLSK 492

  Fly   502 VIHSFVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICDYHEFANAPDAYQGF-----EVHVA 561
            ::   :.|:.:||:.|.|...                |:..:.|:    |..:|:     ....|
  Rat   493 MV---MKYWANFARNGSPNGG----------------GLPHWPEY----DQKEGYLKIGASTQAA 534

  Fly   562 SEFQTDRVNLWSHI 575
            ...:...|..||.:
  Rat   535 QRLKDKEVAFWSEL 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	162/540 (30%)
Ces1d	NP_579829.3	COesterase	24..545	CDD:278561	170/593 (29%)
		Aes	<121..>239	CDD:223730	58/123 (47%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336148
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950