Protein Alignment Jhe and CEL

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_001798.3
• Gene: CEL / 1056
• HGNCID: 1848
• Length: 753
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 174/578 - (30%)
• Similarity: 260/578 - (44%)
• Gaps: 109/578 - (18%)

  Fly     7 LQLLLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKGTNLQ-GYQSERFEAFMGIPYALPPIGD 70
            |||::||...      |.|:|:..:|.......|.::|.|.: |...:..:.|.|||:|.|   .
Human     4 LQLVVLGLTC------CWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAP---T 59

  Fly    71 LRFSNPKVMPKLLGMYDASAPKMDCIQKNYLLPTPVVYGDEDCLYLNVYRPEIRKSA---LPVMV 132
            ....||:..|...|...|...|..|:|..  :.....||||||||||::.|:.||..   ||||:
Human    60 KALENPQPHPGWQGTLKAKNFKKRCLQAT--ITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMI 122

  Fly   133 YIHGGGFFGGSAGPGVTGPEYFMDSGE-------VILVTMAYRLGPFGFLSTQDAVMSGNFGLKD 190
            :|:||.|..|| |.|......::..||       ||:||..||:||.|||||.||.:.||:||:|
Human   123 WIYGGAFLMGS-GHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRD 186

  Fly   191 QNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAE 255
            |::|:.||:|||..|||||..:|:||:||||.:..:..|||.:.||..|.||.||.|..|:.|.:
Human   187 QHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQK 251

  Fly   256 QPLEQARLLAEFADVP---DARNLSTVKLTKALRRINATKLLNAGDGLKYWDVDHMTNFRPVVEE 317
            .||..|:.:||....|   .||....:|:|.......|.|:..|  ||:| .:.|...|.||::
Human   252 NPLFWAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLA--GLEY-PMLHYVGFVPVID- 312

  Fly   318 GLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAV------RVVNILGNETLRQSFNLRFDEL 376
                ..|:.|.|:::.|..  ..|..:.||...:|.:      ..:| .||:.:.:.   .|.:|
Human   313 ----GDFIPADPINLYANA--ADIDYIAGTNNMDGHIFASIDMPAIN-KGNKKVTEE---DFYKL 367

  Fly   377 LQELL-------------EFPASFSQD-----RREKMMDLLVEVYF-------QGQHEVNELTVQ 416
            :.|..             .:..|::||     :::.::|...:|.|       ..||..|..:.:
Human   368 VSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAKSAK 432

  Fly   417 GFMNLISDRGFKQPLYNTIHKNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLL 481
            .:..|.|... :.|:|            |.::                        |..|.||:.
Human   433 TYAYLFSHPS-RMPVY------------PKWV------------------------GADHADDIQ 460

  Fly   482 YLFRSPLLFPDFQRNSTEAKVIHSFVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDG 539
            |:|..|...|...| ..:..|..:.:.|:.:|||.|.|...:|..|...|...:...|
Human   461 YVFGKPFATPTGYR-PQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSG 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	162/533 (30%)
CEL	NP_001798.3	Heparin-binding	21..121		34/104 (33%)
		COesterase	26..542	CDD:395084	165/550 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	555..753
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745
		Mucin-like	584..677	CDD:464997
		Mucin-like	639..731	CDD:464997